O'Brien S - Search Results

1

Relative Biological Effectiveness (RBE) of [⁶⁴Cu]Cu and [¹⁷⁷Lu]Lu-NOTA-panitumumab F (ab')₂ radioimmunotherapeutic agents vs. γ-radiation for decreasing the clonogenic survival in vitro of human pancreatic ductal adenocarcinoma (PDAC) cells.

Boyle AJ, Cai Z, O'Brien S, Crick J, Angers S, Reilly RM. Boyle AJ, et al. Nucl Med Biol. 2023 Jul-Aug;122-123:108367. doi: 10.1016/j.nucmedbio.2023.108367. Epub 2023 Jul 17. Nucl Med Biol. 2023. PMID: 37506639

2

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. Tao Y, et al. Elife. 2019 Aug 27;8:e46134. doi: 10.7554/eLife.46134. Elife. 2019. PMID: 31452509 Free PMC article.

3

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.

Mis M, O'Brien S, Steinhart Z, Lin S, Hart T, Moffat J, Angers S. Mis M, et al. J Cell Biol. 2020 Feb 3;219(2):e201903017. doi: 10.1083/jcb.201903017. J Cell Biol. 2020. PMID: 31881079 Free PMC article.

4

SCF^FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination.

O'Brien S, Kelso S, Steinhart Z, Orlicky S, Mis M, Kim Y, Lin S, Sicheri F, Angers S. O'Brien S, et al. EMBO Rep. 2022 Dec 6;23(12):e55044. doi: 10.15252/embr.202255044. Epub 2022 Oct 24. EMBO Rep. 2022. PMID: 36278408 Free PMC article.

5

Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964.

Kelso S, O'Brien S, Kurinov I, Angers S, Sicheri F. Kelso S, et al. Structure. 2022 Dec 1;30(12):1615-1625.e4. doi: 10.1016/j.str.2022.10.003. Epub 2022 Nov 2. Structure. 2022. PMID: 36327972 Free PMC article.

6

Modulation of Wnt-β-catenin signaling with antibodies: therapeutic opportunities and challenges.

O'Brien S, Chidiac R, Angers S. O'Brien S, et al. Trends Pharmacol Sci. 2023 Jun;44(6):354-365. doi: 10.1016/j.tips.2023.03.008. Epub 2023 Apr 19. Trends Pharmacol Sci. 2023. PMID: 37085400 Review.

7

FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe.

O'Brien S, Ubhi T, Wolf L, Gandhi K, Lin S, Chaudary N, Dhani NC, Milosevic M, Brown GW, Angers S. O'Brien S, et al. Cancer Res Commun. 2023 Dec 21;3(12):2596-2607. doi: 10.1158/2767-9764.CRC-23-0306. Cancer Res Commun. 2023. PMID: 38032106 Free PMC article.

8

CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality.

Sack T, Dhavarasa P, Szames D, O'Brien S, Angers S, Kelley SO. Sack T, et al. ACS Chem Biol. 2023 Dec 15;18(12):2599-2609. doi: 10.1021/acschembio.3c00620. Epub 2023 Dec 6. ACS Chem Biol. 2023. PMID: 38054633

9

Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumors.

Nelson BE, O'Brien S, Sheth RA, Hong DS, Naing A, Zhang X, Xu A, Hamuro L, Suryawanshi R, McKinley D, Novosiadly RD, Piha-Paul SA. Nelson BE, et al. Among authors: o brien s. J Immunother Cancer. 2025 Jan 16;13(1):e010013. doi: 10.1136/jitc-2024-010013. J Immunother Cancer. 2025. PMID: 39824531 Clinical Trial.

10

Acinetobacter spp. in neonatal sepsis: an urgent global threat.

Pillay K, Ray-Chaudhuri A, O'Brien S, Heath P, Sharland M. Pillay K, et al. Among authors: o brien s. Front Antibiot. 2024 Sep 3;3:1448071. doi: 10.3389/frabi.2024.1448071. eCollection 2024. Front Antibiot. 2024. PMID: 39816262 Free PMC article. Review.

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