Xie S - Search Results

1

Small-Molecule Hydrophobic Tagging: A Promising Strategy of Druglike Technology for Targeted Protein Degradation.

Xie S, Zhu J, Li J, Zhan F, Yao H, Xu J, Xu S. Xie S, et al. J Med Chem. 2023 Aug 24;66(16):10917-10933. doi: 10.1021/acs.jmedchem.3c00736. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535706 Review.

2

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

Yao H, Xu F, Wang G, Xie S, Li W, Yao H, Ma C, Zhu Z, Xu J, Xu S. Yao H, et al. Among authors: xie s. Eur J Med Chem. 2019 Apr 1;167:485-498. doi: 10.1016/j.ejmech.2019.02.014. Epub 2019 Feb 12. Eur J Med Chem. 2019. PMID: 30784881

3

Controllable thioester-based hydrogen sulfide slow-releasing donors as cardioprotective agents.

Yao H , Luo S , Liu J , Xie S , Liu Y , Xu J , Zhu Z , Xu S . Yao H , et al. Among authors: xie s. Chem Commun (Camb). 2019 May 28;55(44):6193-6196. doi: 10.1039/c9cc02829c. Chem Commun (Camb). 2019. PMID: 31070620

4

Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates.

Xie S, Li X, Yu H, Zhang P, Wang J, Wang C, Xu S, Wu Z, Liu J, Zhu Z, Xu J. Xie S, et al. Bioorg Med Chem. 2019 Jul 1;27(13):2764-2770. doi: 10.1016/j.bmc.2019.05.004. Epub 2019 May 6. Bioorg Med Chem. 2019. PMID: 31078380

5

Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer.

Yao H, Xie S, Ma X, Liu J, Wu H, Lin A, Yao H, Li D, Xu S, Yang DH, Chen ZS, Xu J. Yao H, et al. Among authors: xie s. J Med Chem. 2020 Aug 13;63(15):8157-8178. doi: 10.1021/acs.jmedchem.0c00408. Epub 2020 Jul 21. J Med Chem. 2020. PMID: 32610904

6

Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).

Xie S, Sun Y, Liu Y, Li X, Li X, Zhong W, Zhan F, Zhu J, Yao H, Yang DH, Chen ZS, Xu J, Xu S. Xie S, et al. J Med Chem. 2021 Jul 8;64(13):9120-9140. doi: 10.1021/acs.jmedchem.1c00270. Epub 2021 Jun 28. J Med Chem. 2021. PMID: 34176264

7

Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14- hydroxyl group from oridonin.

Liu J, Xie S, Shao X, Xue S, Du P, Wu H, Xu S, Chen ZS, Yang DH, Xu J, Yao H. Liu J, et al. Among authors: xie s. Eur J Med Chem. 2022 Mar 5;231:114155. doi: 10.1016/j.ejmech.2022.114155. Epub 2022 Jan 29. Eur J Med Chem. 2022. PMID: 35121201

8

Design, synthesis, and biological evaluation of novel protopanoxadiol derivatives based PROTACs technology for the treatment of lung cancer.

Wang P, Zhu H, Liu J, Xie S, Xu S, Chen Y, Xu J, Zhao Y, Zhu Z, Xu J. Wang P, et al. Among authors: xie s. Bioorg Chem. 2023 Feb;131:106327. doi: 10.1016/j.bioorg.2022.106327. Epub 2022 Dec 16. Bioorg Chem. 2023. PMID: 36549254

9

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation.

Xie S, Zhan F, Zhu J, Sun Y, Zhu H, Liu J, Chen J, Zhu Z, Yang DH, Chen ZS, Yao H, Xu J, Xu S. Xie S, et al. Angew Chem Int Ed Engl. 2023 Mar 20;62(13):e202217246. doi: 10.1002/anie.202217246. Epub 2023 Feb 8. Angew Chem Int Ed Engl. 2023. PMID: 36670545

10

Advances of bioorthogonal coupling reactions in drug development.

Zhan F, Zhu J, Xie S, Xu J, Xu S. Zhan F, et al. Among authors: xie s. Eur J Med Chem. 2023 May 5;253:115338. doi: 10.1016/j.ejmech.2023.115338. Epub 2023 Apr 5. Eur J Med Chem. 2023. PMID: 37037138 Review.

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