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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik SW, Liu Q, Tansey WP. Howard GC, et al. Among authors: savona mr. bioRxiv [Preprint]. 2024 Jan 10:2023.07.26.550648. doi: 10.1101/2023.07.26.550648. bioRxiv. 2024. Update in: Elife. 2024 Apr 29;12:RP90683. doi: 10.7554/eLife.90683 PMID: 37546802 Free PMC article. Updated. Preprint.
TLR3 agonism augments CD47 inhibition in acute myeloid leukemia.
Ramsey HE, Gorska AE, Smith BN, Monteith AJ, Fuller L, Arrate MP, Savona MR. Ramsey HE, et al. Among authors: savona mr. Haematologica. 2024 Jul 1;109(7):2111-2121. doi: 10.3324/haematol.2023.283850. Haematologica. 2024. PMID: 38152031 Free PMC article.
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik S, Liu Q, Tansey WP. Howard GC, et al. Among authors: savona mr. Elife. 2024 Apr 29;12:RP90683. doi: 10.7554/eLife.90683. Elife. 2024. PMID: 38682900 Free PMC article.
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies.
Meyer CT, Smith BN, Wang J, Teuscher KB, Grieb BC, Howard GC, Silver AJ, Lorey SL, Stott GM, Moore WJ, Lee T, Savona MR, Weissmiller AM, Liu Q, Quaranta V, Fesik SW, Tansey WP. Meyer CT, et al. Among authors: savona mr. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2408889121. doi: 10.1073/pnas.2408889121. Epub 2024 Aug 21. Proc Natl Acad Sci U S A. 2024. PMID: 39167600
PheMIME: An Interactive Web App and Knowledge Base for Phenome-Wide, Multi-Institutional Multimorbidity Analysis.
Zhang S, Strayer N, Vessels T, Choi K, Wang GW, Li Y, Bejan CA, Hsi RS, Bick AG, Velez Edwards DR, Savona MR, Philips EJ, Pulley J, Self WH, Hopkins WC, Roden DM, Smoller JW, Ruderfer DM, Xu Y. Zhang S, et al. Among authors: savona mr. medRxiv [Preprint]. 2023 Jul 30:2023.07.23.23293047. doi: 10.1101/2023.07.23.23293047. medRxiv. 2023. Update in: J Am Med Inform Assoc. 2024 Nov 1;31(11):2440-2446. doi: 10.1093/jamia/ocae182 PMID: 37547012 Free PMC article. Updated. Preprint.
Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics.
Mack T, Vlasschaert C, von Beck K, Silver AJ, Heimlich JB, Poisner H, Condon HR, Ulloa J, Sochacki AL, Spaulding TP, Kishtagari A, Bejan CA, Xu Y, Savona MR, Jones A, Bick AG. Mack T, et al. Among authors: savona mr. J Mol Diagn. 2024 Jul;26(7):563-573. doi: 10.1016/j.jmoldx.2024.03.007. Epub 2024 Apr 6. J Mol Diagn. 2024. PMID: 38588769 Free PMC article.
Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository.
Shannon ML, Heimlich JB, Olson S, Debevec A, Copeland Z, Kishtagari A, Vlasschaert C, Snider C, Silver AJ, Brown D, Spaulding T, Bhatta M, Pugh K, Stockton SS, Ulloa J, Xu Y, Baljevic M, Moslehi J, Jahangir E, Ferrell PB, Slosky D, Bick AG, Savona MR. Shannon ML, et al. Among authors: savona mr. Blood Adv. 2024 Jul 9;8(13):3453-3463. doi: 10.1182/bloodadvances.2023011510. Blood Adv. 2024. PMID: 38608257 Free PMC article.
PheMIME: an interactive web app and knowledge base for phenome-wide, multi-institutional multimorbidity analysis.
Zhang S, Strayer N, Vessels T, Choi K, Wang GW, Li Y, Bejan CA, Hsi RS, Bick AG, Velez Edwards DR, Savona MR, Phillips EJ, Pulley JM, Self WH, Hopkins WC, Roden DM, Smoller JW, Ruderfer DM, Xu Y. Zhang S, et al. Among authors: savona mr. J Am Med Inform Assoc. 2024 Nov 1;31(11):2440-2446. doi: 10.1093/jamia/ocae182. J Am Med Inform Assoc. 2024. PMID: 39127052 Free PMC article.
Germline genetics, disease, and exposure to medication influence longitudinal dynamics of clonal hematopoiesis.
Mack T, Pershad Y, Vlasschaert C, Bejan CA, Heimlich JB, Li Y, Mickels NA, Van Amburg JC, Ulloa J, Silver AJ, Luo LY, Jones A, Ferrell PB, Kishtagari A, Xu Y, Savona MR, Bick AG. Mack T, et al. Among authors: savona mr. Haematologica. 2024 Nov 14. doi: 10.3324/haematol.2024.286513. Online ahead of print. Haematologica. 2024. PMID: 39540221 Free article.
Pathogenesis and inflammaging in myelodysplastic syndrome.
Villaume MT, Savona MR. Villaume MT, et al. Among authors: savona mr. Haematologica. 2024 Oct 24. doi: 10.3324/haematol.2023.284944. Online ahead of print. Haematologica. 2024. PMID: 39445405 Free article.
156 results