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Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Graziano V, Dannhorn A, Hulme H, Williamson K, Buckley H, Karim SA, Wilson M, Lee SY, Kaistha BP, Islam S, Thaventhiran JED, Richards FM, Goodwin R, Brais R, Morton JP, Dovedi SJ, Schuller AG, Eyles J, Jodrell DI. Graziano V, et al. Among authors: eyles j. J Immunother Cancer. 2023 Aug;11(8):e006457. doi: 10.1136/jitc-2022-006457. J Immunother Cancer. 2023. PMID: 37553182 Free PMC article.
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models.
Kaistha BP, Kar G, Dannhorn A, Watkins A, Opoku-Ansah G, Ilieva K, Mullins S, Anderton J, Galvani E, Garcon F, Lapointe JM, Brown L, Hair J, Slidel T, Luheshi N, Ryan K, Hardaker E, Dovedi S, Kumar R, Wilkinson RW, Hammond SA, Eyles J. Kaistha BP, et al. Among authors: eyles j. Cancer Biol Ther. 2024 Dec 31;25(1):2296048. doi: 10.1080/15384047.2023.2296048. Epub 2024 Jan 11. Cancer Biol Ther. 2024. PMID: 38206570 Free PMC article.
Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance.
Krykbaeva I, Bridges K, Damsky W, Pizzurro GA, Alexander AF, McGeary MK, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss SA, Olino K, Kaech SM, Kluger HM, Miller-Jensen K, Bosenberg M. Krykbaeva I, et al. Among authors: eyles j. Cancer Immunol Res. 2023 Oct 4;11(10):1332-1350. doi: 10.1158/2326-6066.CIR-22-0699. Cancer Immunol Res. 2023. PMID: 37478171
CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells.
Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM, Sanz-Moreno V. Samain R, et al. Among authors: eyles j. Sci Adv. 2023 Oct 20;9(42):eadi0244. doi: 10.1126/sciadv.adi0244. Epub 2023 Oct 18. Sci Adv. 2023. PMID: 37851808 Free PMC article.
A mechanistic PK/PD model of AZD0171 (anti-LIF) to support Phase II dose selection.
Shahraz A, Penney M, Candido J, Opoku-Ansah G, Neubauer M, Eyles J, Ojo O, Liu N, Luheshi NM, Phipps A, Vishwanathan K. Shahraz A, et al. Among authors: eyles j. CPT Pharmacometrics Syst Pharmacol. 2024 Oct;13(10):1670-1681. doi: 10.1002/psp4.13204. Epub 2024 Jul 23. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 39041713 Free PMC article.
Effects of Arthroscopic Surgery and Non-Surgical Therapy on Hip Contact Forces in Femoroacetabular Impingement Syndrome.
Nasseri A, Diamond LE, Pizzolato C, Savage TN, Grant T, Besier T, Molnar R, Tran P, Singh P, Murphy N, Foster NE, Hall M, Spiers L, Bennell KL, O'Donnell J, Eyles J, Fary C, Lloyd DG, Hunter DJ, Saxby DJ. Nasseri A, et al. Among authors: eyles j. Med Sci Sports Exerc. 2024 Dec 9. doi: 10.1249/MSS.0000000000003624. Online ahead of print. Med Sci Sports Exerc. 2024. PMID: 39652512
MuscleMap: An Open-Source, Community-Supported Consortium for Whole-Body Quantitative MRI of Muscle.
McKay MJ, Weber KA 2nd, Wesselink EO, Smith ZA, Abbott R, Anderson DB, Ashton-James CE, Atyeo J, Beach AJ, Burns J, Clarke S, Collins NJ, Coppieters MW, Cornwall J, Crawford RJ, De Martino E, Dunn AG, Eyles JP, Feng HJ, Fortin M, Franettovich Smith MM, Galloway G, Gandomkar Z, Glastras S, Henderson LA, Hides JA, Hiller CE, Hilmer SN, Hoggarth MA, Kim B, Lal N, LaPorta L, Magnussen JS, Maloney S, March L, Nackley AG, O'Leary SP, Peolsson A, Perraton Z, Pool-Goudzwaard AL, Schnitzler M, Seitz AL, Semciw AI, Sheard PW, Smith AC, Snodgrass SJ, Sullivan J, Tran V, Valentin S, Walton DM, Wishart LR, Elliott JM. McKay MJ, et al. Among authors: eyles jp. J Imaging. 2024 Oct 22;10(11):262. doi: 10.3390/jimaging10110262. J Imaging. 2024. PMID: 39590726 Free PMC article. Review.
Building the OAChangeMap to Improve the Service Delivery of the New South Wales Osteoarthritis Chronic Care Program: A Worked Example of Using a Codesign Framework.
Eyles JP, Kobayashi S, Duong V, Hunter DJ, Avdalis C, Buttel T, Dawson G, Dório M, D'Souza N, Foster K, Maka K, March MK, Menz F, Pratt C, Rankin NM, Richardson D, Thompson J, Strong C, Bowden JL. Eyles JP, et al. Arthritis Care Res (Hoboken). 2024 Oct 28. doi: 10.1002/acr.25454. Online ahead of print. Arthritis Care Res (Hoboken). 2024. PMID: 39466983
273 results