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An anchor-tether 'hindered' HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model.
Tibbs GR, Uprety R, Warren JD, Beyer NP, Joyce RL, Ferrer MA, Mellado W, Wong VSC, Goldberg DC, Cohen MW, Costa CJ, Li Z, Zhang G, Dephoure NE, Barman DN, Sun D, Ingólfsson HI, Sauve AA, Willis DE, Goldstein PA. Tibbs GR, et al. Among authors: zhang g. Br J Anaesth. 2023 Oct;131(4):745-763. doi: 10.1016/j.bja.2023.06.067. Epub 2023 Aug 9. Br J Anaesth. 2023. PMID: 37567808 Free PMC article.
Epinephrine inhibits PI3Kα via the Hippo kinases.
Lin TY, Ramsamooj S, Perrier T, Liberatore K, Lantier L, Vasan N, Karukurichi K, Hwang SK, Kesicki EA, Kastenhuber ER, Wiederhold T, Yaron TM, Huntsman EM, Zhu M, Ma Y, Paddock MN, Zhang G, Hopkins BD, McGuinness O, Schwartz RE, Ersoy BA, Cantley LC, Johnson JL, Goncalves MD. Lin TY, et al. Among authors: zhang g. Cell Rep. 2023 Dec 26;42(12):113535. doi: 10.1016/j.celrep.2023.113535. Epub 2023 Dec 4. Cell Rep. 2023. PMID: 38060450 Free PMC article.
Real-Time, in Vivo Correlation of Molecular Structure with Drug Distribution in the Brain Striatum Following Convection Enhanced Delivery.
Tosi U, Kommidi H, Bellat V, Marnell CS, Guo H, Adeuyan O, Schweitzer ME, Chen N, Su T, Zhang G, Maachani UB, Pisapia DJ, Law B, Souweidane MM, Ting R. Tosi U, et al. Among authors: zhang g. ACS Chem Neurosci. 2019 May 15;10(5):2287-2298. doi: 10.1021/acschemneuro.8b00607. Epub 2019 Mar 6. ACS Chem Neurosci. 2019. PMID: 30838861
Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma.
Torrini C, Nguyen TTT, Shu C, Mela A, Humala N, Mahajan A, Seeley EH, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Torrini C, et al. Among authors: zhang g. Mol Cell. 2022 Aug 18;82(16):3061-3076.e6. doi: 10.1016/j.molcel.2022.06.030. Epub 2022 Aug 9. Mol Cell. 2022. PMID: 35948010 Free PMC article.
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