Okafor CD - Search Results

1

The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.

Mays SG, Hercules D, Ortlund EA, Okafor CD. Mays SG, et al. Among authors: okafor cd. Protein Sci. 2023 Oct;32(10):e4754. doi: 10.1002/pro.4754. Protein Sci. 2023. PMID: 37572334 Free PMC article.

2

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.

Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Mays SG, et al. Among authors: okafor cd. J Biol Chem. 2016 Dec 2;291(49):25281-25291. doi: 10.1074/jbc.M116.753541. Epub 2016 Sep 30. J Biol Chem. 2016. PMID: 27694446 Free PMC article.

3

Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.

Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Mays SG, et al. Among authors: okafor cd. Mol Pharmacol. 2017 Jul;92(1):1-11. doi: 10.1124/mol.117.108514. Epub 2017 Mar 31. Mol Pharmacol. 2017. PMID: 28363985 Free PMC article.

4

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.

Weikum ER, Okafor CD, D'Agostino EH, Colucci JK, Ortlund EA. Weikum ER, et al. Among authors: okafor cd. Mol Pharmacol. 2017 Jul;92(1):12-21. doi: 10.1124/mol.117.108506. Epub 2017 Apr 10. Mol Pharmacol. 2017. PMID: 28396564 Free PMC article.

5

Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.

Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Okafor CD, et al. Structure. 2018 Jan 2;26(1):118-129.e3. doi: 10.1016/j.str.2017.11.018. Epub 2017 Dec 21. Structure. 2018. PMID: 29276038 Free PMC article.

6

The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor.

Frank F, Okafor CD, Ortlund EA. Frank F, et al. Among authors: okafor cd. Sci Rep. 2018 Sep 10;8(1):13497. doi: 10.1038/s41598-018-31812-9. Sci Rep. 2018. PMID: 30201977 Free PMC article.

7

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.

Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R, Moore DD, Calvert JW, Jui NT, Ortlund EA. Mays SG, et al. Among authors: okafor cd. J Med Chem. 2019 Dec 26;62(24):11022-11034. doi: 10.1021/acs.jmedchem.9b00753. Epub 2019 Sep 6. J Med Chem. 2019. PMID: 31419141 Free PMC article.

8

Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors.

Okafor CD, Hercules D, Kell SA, Ortlund EA. Okafor CD, et al. Structure. 2020 Feb 4;28(2):196-205.e3. doi: 10.1016/j.str.2019.11.012. Epub 2019 Dec 9. Structure. 2020. PMID: 31831214 Free article.

9

Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.

Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Tillman MC, et al. Among authors: okafor cd. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22080-22089. doi: 10.1073/pnas.2003877117. Epub 2020 Aug 20. Proc Natl Acad Sci U S A. 2020. PMID: 32820071 Free PMC article.

10

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.

Moody JC, Qadota H, Reedy AR, Okafor CD, Shanmugan N, Matsunaga Y, Christian CJ, Ortlund EA, Benian GM. Moody JC, et al. Among authors: okafor cd. Nat Commun. 2020 Oct 6;11(1):5010. doi: 10.1038/s41467-020-18852-4. Nat Commun. 2020. PMID: 33024114 Free PMC article.

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