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A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers.
Jones NS, Kshirsagar S, Mohanan V, Ramakrishnan V, Di Nucci F, Ma L, Mao J, Ding H, Klabunde S, Vucic D, Pan L, Lekkerkerker AN, Chen Y, Rothenberg ME. Jones NS, et al. Clin Transl Sci. 2023 Oct;16(10):1997-2009. doi: 10.1111/cts.13607. Epub 2023 Aug 24. Clin Transl Sci. 2023. PMID: 37596814 Free PMC article. Clinical Trial.
Efficacy, Safety, and Pharmacodynamic Effects of the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853) in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Trial.
Isenberg D, Furie R, Jones NS, Guibord P, Galanter J, Lee C, McGregor A, Toth B, Rae J, Hwang O, Desai R, Lokku A, Ramamoorthi N, Hackney JA, Miranda P, de Souza VA, Jaller-Raad JJ, Maura Fernandes A, Garcia Salinas R, Chinn LW, Townsend MJ, Morimoto AM, Tuckwell K. Isenberg D, et al. Among authors: jones ns. Arthritis Rheumatol. 2021 Oct;73(10):1835-1846. doi: 10.1002/art.41811. Epub 2021 Aug 24. Arthritis Rheumatol. 2021. PMID: 34042314 Clinical Trial.
Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma.
Rhee H, Henderson LM, Bauer RN, Wong K, Staton TL, Choy DF, Banerjee P, Poon V, Yoshida K, Chen C, Long K, Sperinde G, Laing ST, Jones NS, Glickstein SB, Dayal P, Fong A, Dash A, Pulka G, Leaker B, Singh D, Bradding P. Rhee H, et al. Among authors: jones ns. Allergy. 2024 Nov;79(11):2993-3004. doi: 10.1111/all.16309. Epub 2024 Sep 9. Allergy. 2024. PMID: 39250147 Clinical Trial.
355 results