Mao J - Search Results

1

A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers.

Jones NS, Kshirsagar S, Mohanan V, Ramakrishnan V, Di Nucci F, Ma L, Mao J, Ding H, Klabunde S, Vucic D, Pan L, Lekkerkerker AN, Chen Y, Rothenberg ME. Jones NS, et al. Among authors: mao j. Clin Transl Sci. 2023 Oct;16(10):1997-2009. doi: 10.1111/cts.13607. Epub 2023 Aug 24. Clin Transl Sci. 2023. PMID: 37596814 Free PMC article. Clinical Trial.

2

Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone.

Chen Y, Mao J, Hop CE. Chen Y, et al. Among authors: mao j. Drug Metab Dispos. 2015 Feb;43(2):182-9. doi: 10.1124/dmd.114.059311. Epub 2014 Oct 16. Drug Metab Dispos. 2015. PMID: 25324279 Clinical Trial.

3

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug-Drug Interaction Prediction.

Chen Y, Ma F, Lu T, Budha N, Jin JY, Kenny JR, Wong H, Hop CE, Mao J. Chen Y, et al. Among authors: mao j. Clin Pharmacokinet. 2016 Jun;55(6):735-49. doi: 10.1007/s40262-015-0352-5. Clin Pharmacokinet. 2016. PMID: 26692192

4

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.

Mao J, Tay S, Khojasteh CS, Chen Y, Hop CE, Kenny JR. Mao J, et al. Pharm Res. 2016 May;33(5):1204-19. doi: 10.1007/s11095-016-1865-9. Epub 2016 Feb 11. Pharm Res. 2016. PMID: 26869174

5

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.

Mao J, Fan P, Wong S, Wang J, Ismaili MHA, Dean B, Hop CECA, Wright M, Chen Y. Mao J, et al. Pharm Res. 2017 Nov;34(11):2403-2414. doi: 10.1007/s11095-017-2246-8. Epub 2017 Aug 16. Pharm Res. 2017. PMID: 28815392

6

Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling.

Mao J, Doshi U, Wright M, Hop CECA, Li AP, Chen Y. Mao J, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Apr;7(4):251-258. doi: 10.1002/psp4.12283. Epub 2018 Feb 13. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29388346 Free PMC article.

7

Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.

Chen Y, Zhu R, Ma F, Mao J, Chen EC, Choo EF, Sahasranaman S, Liu L. Chen Y, et al. Among authors: mao j. Biopharm Drug Dispos. 2018 Nov;39(9):420-430. doi: 10.1002/bdd.2159. Epub 2018 Nov 20. Biopharm Drug Dispos. 2018. PMID: 30335192

8

Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma.

Bowman CM, Chen E, Chen L, Chen YC, Liang X, Wright M, Chen Y, Mao J. Bowman CM, et al. Among authors: mao j. Drug Metab Dispos. 2020 Jan;48(1):18-24. doi: 10.1124/dmd.119.088948. Epub 2019 Nov 7. Drug Metab Dispos. 2020. PMID: 31699807

9

Physiologically Based Pharmacokinetic Model-Informed Drug Development for Polatuzumab Vedotin: Label for Drug-Drug Interactions Without Dedicated Clinical Trials.

Samineni D, Ding H, Ma F, Shi R, Lu D, Miles D, Mao J, Li C, Jin J, Wright M, Girish S, Chen Y. Samineni D, et al. Among authors: mao j. J Clin Pharmacol. 2020 Oct;60 Suppl 1:S120-S131. doi: 10.1002/jcph.1718. J Clin Pharmacol. 2020. PMID: 33205435

10

Examination of Physiologically-Based Pharmacokinetic Models of Rosuvastatin.

Bowman CM, Ma F, Mao J, Chen Y. Bowman CM, et al. Among authors: mao j. CPT Pharmacometrics Syst Pharmacol. 2021 Jan;10(1):5-17. doi: 10.1002/psp4.12571. Epub 2020 Dec 15. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33220025 Free PMC article. Review.

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