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A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers.
Jones NS, Kshirsagar S, Mohanan V, Ramakrishnan V, Di Nucci F, Ma L, Mao J, Ding H, Klabunde S, Vucic D, Pan L, Lekkerkerker AN, Chen Y, Rothenberg ME. Jones NS, et al. Among authors: rothenberg me. Clin Transl Sci. 2023 Oct;16(10):1997-2009. doi: 10.1111/cts.13607. Epub 2023 Aug 24. Clin Transl Sci. 2023. PMID: 37596814 Free PMC article. Clinical Trial.
Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc).
Yu Y, Rothenberg ME, Ding HT, Brekkan A, Sperinde G, Harder B, Zhang R, Owen R, Kassir N, Lekkerkerker AN. Yu Y, et al. Among authors: rothenberg me. J Pharmacokinet Pharmacodyn. 2024 Apr;51(2):141-153. doi: 10.1007/s10928-023-09888-2. Epub 2023 Oct 20. J Pharmacokinet Pharmacodyn. 2024. PMID: 37864000
Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects.
Prado-Acosta M, Jeong S, Utrero-Rico A, Goncharov T, Webster JD, Holler E, Morales G, Dellepiane S, Levine JE, Rothenberg ME, Vucic D, Ferrara JLM. Prado-Acosta M, et al. Among authors: rothenberg me. Sci Transl Med. 2023 Dec 20;15(727):eadf8366. doi: 10.1126/scitranslmed.adf8366. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117900 Free PMC article.
A randomized phase 2 study of efmarodocokin alfa, an IL-22 agonist, versus vedolizumab in patients with ulcerative colitis.
Danese S, Rothenberg ME, Lim JJ, Ding HT, McBride JM, Chen Y, Dash A, Mar JS, Keir M, Peyrin-Biroulet L, Panes J, Colombel JF, Feagan B, Valentine JF, Schreiber S. Danese S, et al. Among authors: rothenberg me. Clin Gastroenterol Hepatol. 2024 Dec 16:S1542-3565(24)01096-6. doi: 10.1016/j.cgh.2024.11.013. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 39694207 Free article.
Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals.
Sun KY, Bai X, Chen S, Bao S, Zhang C, Kapoor M, Backman J, Joseph T, Maxwell E, Mitra G, Gorovits A, Mansfield A, Boutkov B, Gokhale S, Habegger L, Marcketta A, Locke AE, Ganel L, Hawes A, Kessler MD, Sharma D, Staples J, Bovijn J, Gelfman S, Di Gioia A, Rajagopal VM, Lopez A, Varela JR, Alegre-Díaz J, Berumen J, Tapia-Conyer R, Kuri-Morales P, Torres J, Emberson J, Collins R; Regeneron Genetics Center; RGC-ME Cohort Partners; Cantor M, Thornton T, Kang HM, Overton JD, Shuldiner AR, Cremona ML, Nafde M, Baras A, Abecasis G, Marchini J, Reid JG, Salerno W, Balasubramanian S. Sun KY, et al. Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08571-x. Online ahead of print. Nature. 2025. PMID: 39779867 No abstract available.
Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children.
Brunwasser SM, Gebretsadik T, Satish A, Cole JC, Dupont WD, Joseph C, Bendixsen CG, Calatroni A, Arbes SJ Jr, Fulkerson PC, Sanders J, Bacharier LB, Camargo CA Jr, Johnson CC, Furuta GT, Gruchalla RS, Gupta RS, Khurana Hershey GK, Jackson DJ, Kattan M, Liu A, O'Connor GT, Rivera-Spoljaric K, Phipatanakul W, Rothenberg ME, Seibold MA, Seroogy CM, Teach SJ, Zoratti EM, Togias A, Hartert TV; HEROS study group. Brunwasser SM, et al. Among authors: rothenberg me. Prev Med Rep. 2024 Nov 27;49:102936. doi: 10.1016/j.pmedr.2024.102936. eCollection 2025 Jan. Prev Med Rep. 2024. PMID: 39697187 Free PMC article.
581 results