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Sarcoplasmic reticulum calcium ATPase (SERCA) proteolysis by matrix metalloproteinase-2 contributes to vascular dysfunction in early hypertension.
Blascke de Mello MM, Neves VGO, Parente JM, Pernomian L, de Oliveira IS, Pedersoli CA, Awata WMC, Tirapelli CR, Arantes EC, Tostes RCA, Schulz R, Castro MM. Blascke de Mello MM, et al. Eur J Pharmacol. 2024 Nov 15;983:176981. doi: 10.1016/j.ejphar.2024.176981. Epub 2024 Sep 4. Eur J Pharmacol. 2024. PMID: 39241943
The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension.
Pernomian L, Blascke de Mello MM, Parente JM, Sanches-Lopes JM, Tanus-Santos JE, Parreiras E Silva LT, Antunes-Rodrigues J, da Conceição Dos Santos R, Elias LLK, Fabro AT, Silva CAA, Fazan R Jr, de Castro MM. Pernomian L, et al. Among authors: blascke de mello mm. Life Sci. 2024 Aug 15;351:122819. doi: 10.1016/j.lfs.2024.122819. Epub 2024 Jun 8. Life Sci. 2024. PMID: 38857651
Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension.
de Oliveira Neves VG, Blascke de Mello MM, Rodrigues D, Pernomian L, de Oliveira IS, Parente JM, Arantes EC, Tostes RC, Castro MM. de Oliveira Neves VG, et al. Among authors: blascke de mello mm. Vascul Pharmacol. 2023 Oct;152:107211. doi: 10.1016/j.vph.2023.107211. Epub 2023 Aug 20. Vascul Pharmacol. 2023. PMID: 37607602