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Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension.
de Oliveira Neves VG, Blascke de Mello MM, Rodrigues D, Pernomian L, de Oliveira IS, Parente JM, Arantes EC, Tostes RC, Castro MM. de Oliveira Neves VG, et al. Among authors: pernomian l. Vascul Pharmacol. 2023 Oct;152:107211. doi: 10.1016/j.vph.2023.107211. Epub 2023 Aug 20. Vascul Pharmacol. 2023. PMID: 37607602
Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function.
da Rocha EV, Falchetti F, Pernomian L, de Mello MMB, Parente JM, Nogueira RC, Gomes BQ, Bertozi G, Sanches-Lopes JM, Tanus-Santos JE, Castro MM. da Rocha EV, et al. Among authors: pernomian l. Naunyn Schmiedebergs Arch Pharmacol. 2023 May;396(5):939-949. doi: 10.1007/s00210-022-02349-6. Epub 2022 Dec 17. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 36527481
The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension.
Pernomian L, Blascke de Mello MM, Parente JM, Sanches-Lopes JM, Tanus-Santos JE, Parreiras E Silva LT, Antunes-Rodrigues J, da Conceição Dos Santos R, Elias LLK, Fabro AT, Silva CAA, Fazan R Jr, de Castro MM. Pernomian L, et al. Life Sci. 2024 Aug 15;351:122819. doi: 10.1016/j.lfs.2024.122819. Epub 2024 Jun 8. Life Sci. 2024. PMID: 38857651
Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction.
Prado AF, Pernomian L, Azevedo A, Costa RAP, Rizzi E, Ramos J, Paes Leme AF, Bendhack LM, Tanus-Santos JE, Gerlach RF. Prado AF, et al. Among authors: pernomian l. Redox Biol. 2018 Sep;18:181-190. doi: 10.1016/j.redox.2018.07.005. Epub 2018 Jul 9. Redox Biol. 2018. PMID: 30029165 Free PMC article.
49 results