Wiseman RL - Search Results

1

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.

Ibrahim L, Stanton C, Nutsch K, Nguyen T, Li-Ma C, Ko Y, Lander GC, Wiseman RL, Bollong MJ. Ibrahim L, et al. Among authors: wiseman rl. Cell Chem Biol. 2023 Oct 19;30(10):1295-1302.e4. doi: 10.1016/j.chembiol.2023.07.014. Epub 2023 Aug 23. Cell Chem Biol. 2023. PMID: 37619563 Free PMC article.

2

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. Chen KC, et al. Among authors: wiseman rl. EMBO J. 2017 Aug 1;36(15):2296-2309. doi: 10.15252/embj.201695616. Epub 2017 Jun 27. EMBO J. 2017. PMID: 28655754 Free PMC article.

3

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC. Puchades C, et al. Among authors: wiseman rl. Science. 2017 Nov 3;358(6363):eaao0464. doi: 10.1126/science.aao0464. Science. 2017. PMID: 29097521 Free PMC article.

4

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing.

Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Grandjean JMD, et al. Among authors: wiseman rl. ACS Chem Biol. 2019 Apr 19;14(4):784-795. doi: 10.1021/acschembio.9b00134. Epub 2019 Mar 13. ACS Chem Biol. 2019. PMID: 30821953 Free PMC article.

5

Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.

Puchades C, Ding B, Song A, Wiseman RL, Lander GC, Glynn SE. Puchades C, et al. Among authors: wiseman rl. Mol Cell. 2019 Sep 5;75(5):1073-1085.e6. doi: 10.1016/j.molcel.2019.06.016. Epub 2019 Jul 18. Mol Cell. 2019. PMID: 31327635 Free PMC article.

6

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.

Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC. Shin M, et al. Among authors: wiseman rl. Sci Adv. 2020 May 20;6(21):eaba8404. doi: 10.1126/sciadv.aba8404. eCollection 2020 May. Sci Adv. 2020. PMID: 32490208 Free PMC article.

7

Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3.

Ibrahim L, Mesgarzadeh J, Xu I, Powers ET, Wiseman RL, Bollong MJ. Ibrahim L, et al. Among authors: wiseman rl. Antioxidants (Basel). 2020 Oct 21;9(10):1025. doi: 10.3390/antiox9101025. Antioxidants (Basel). 2020. PMID: 33096892 Free PMC article.

8

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.

Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC. Shin M, et al. Among authors: wiseman rl. Nat Commun. 2021 May 28;12(1):3239. doi: 10.1038/s41467-021-23495-0. Nat Commun. 2021. PMID: 34050165 Free PMC article.

9

Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2.

Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. Rosarda JD, et al. Among authors: wiseman rl. ACS Chem Biol. 2021 Dec 17;16(12):2852-2863. doi: 10.1021/acschembio.1c00810. Epub 2021 Nov 19. ACS Chem Biol. 2021. PMID: 34797633 Free PMC article.

10

Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.

Yang J, Song AS, Wiseman RL, Lander GC. Yang J, et al. Among authors: wiseman rl. J Biol Chem. 2022 Mar;298(3):101694. doi: 10.1016/j.jbc.2022.101694. Epub 2022 Feb 7. J Biol Chem. 2022. PMID: 35143841 Free PMC article.

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