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Mechanistic and Structural Insights on Difluoromethyl-1,3,4-oxadiazole Inhibitors of HDAC6.
Cellupica E, Gaiassi A, Rocchio I, Rovelli G, Pomarico R, Sandrone G, Caprini G, Cordella P, Cukier C, Fossati G, Marchini M, Bebel A, Airoldi C, Palmioli A, Stevenazzi A, Steinkühler C, Vergani B. Cellupica E, et al. Among authors: rocchio i. Int J Mol Sci. 2024 May 28;25(11):5885. doi: 10.3390/ijms25115885. Int J Mol Sci. 2024. PMID: 38892072 Free PMC article.
Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity.
Cellupica E, Caprini G, Cordella P, Cukier C, Fossati G, Marchini M, Rocchio I, Sandrone G, Vanoni MA, Vergani B, Źrubek K, Stevenazzi A, Steinkühler C. Cellupica E, et al. Among authors: rocchio i. J Biol Chem. 2023 Jan;299(1):102800. doi: 10.1016/j.jbc.2022.102800. Epub 2022 Dec 15. J Biol Chem. 2023. PMID: 36528061 Free PMC article.
Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
Vergani B, Sandrone G, Marchini M, Ripamonti C, Cellupica E, Galbiati E, Caprini G, Pavich G, Porro G, Rocchio I, Lattanzio M, Pezzuto M, Skorupska M, Cordella P, Pagani P, Pozzi P, Pomarico R, Modena D, Leoni F, Perego R, Fossati G, Steinkühler C, Stevenazzi A. Vergani B, et al. Among authors: rocchio i. J Med Chem. 2019 Dec 12;62(23):10711-10739. doi: 10.1021/acs.jmedchem.9b01194. Epub 2019 Nov 25. J Med Chem. 2019. PMID: 31710483