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Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment.
Moyano P, García JM, García J, Anadon MJ, Naval MV, Frejo MT, Sola E, Pelayo A, Pino JD. Moyano P, et al. Among authors: naval mv. Ecotoxicol Environ Saf. 2020 Oct 15;203:110975. doi: 10.1016/j.ecoenv.2020.110975. Epub 2020 Jul 14. Ecotoxicol Environ Saf. 2020. PMID: 32678756
Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/β-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment.
Moyano P, García JM, García J, Pelayo A, Muñoz-Calero P, Frejo MT, Anadon MJ, Naval MV, Flores A, Mirat VA, Del Pino J. Moyano P, et al. Among authors: naval mv. Food Chem Toxicol. 2021 Jun;152:112241. doi: 10.1016/j.fct.2021.112241. Epub 2021 Apr 27. Food Chem Toxicol. 2021. PMID: 33930485
Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death.
Flores A, Moyano P, Sola E, García JM, García J, Anadon MJ, Frejo MT, Naval MV, Fernadez MC, Pino JD. Flores A, et al. Among authors: naval mv. Food Chem Toxicol. 2022 Dec;170:113500. doi: 10.1016/j.fct.2022.113500. Epub 2022 Oct 29. Food Chem Toxicol. 2022. PMID: 36374790