Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP.
Yang J, Sundqvist ML, Zheng X, Jiao T, Collado A, Tratsiakovich Y, Mahdi A, Tengbom J, Mergia E, Catrina SB, Zhou Z, Carlström M, Akaike T, Cortese-Krott MM, Weitzberg E, Lundberg JO, Pernow J.
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J Clin Invest. 2023 Sep 1;133(17):e167693. doi: 10.1172/JCI167693.
J Clin Invest. 2023.
PMID: 37655658
Free PMC article.
Clinical Trial.