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Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP.
Yang J, Sundqvist ML, Zheng X, Jiao T, Collado A, Tratsiakovich Y, Mahdi A, Tengbom J, Mergia E, Catrina SB, Zhou Z, Carlström M, Akaike T, Cortese-Krott MM, Weitzberg E, Lundberg JO, Pernow J. Yang J, et al. J Clin Invest. 2023 Sep 1;133(17):e167693. doi: 10.1172/JCI167693. J Clin Invest. 2023. PMID: 37655658 Free PMC article. Clinical Trial.
Dietary nitrate improves cardiac contractility via enhanced cellular Ca²⁺ signaling.
Pironti G, Ivarsson N, Yang J, Farinotti AB, Jonsson W, Zhang SJ, Bas D, Svensson CI, Westerblad H, Weitzberg E, Lundberg JO, Pernow J, Lanner J, Andersson DC. Pironti G, et al. Among authors: yang j. Basic Res Cardiol. 2016 May;111(3):34. doi: 10.1007/s00395-016-0551-8. Epub 2016 Apr 12. Basic Res Cardiol. 2016. PMID: 27071401
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