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Lower magnitude and faster waning of antibody responses to SARS-CoV-2 vaccination in anti-TNF-α-treated IBD patients are linked to lack of activation and expansion of cTfh1 cells and impaired B memory cell formation.
Garner-Spitzer E, Wagner A, Gudipati V, Schoetta AM, Orola-Taus M, Kundi M, Kunert R, Mayrhofer P, Huppa JB, Stockinger H, Carsetti R, Gattinger P, Valenta R, Kratzer B, Sehgal ANA, Pickl WF, Reinisch W, Novacek G, Wiedermann U. Garner-Spitzer E, et al. Among authors: huppa jb. EBioMedicine. 2023 Oct;96:104788. doi: 10.1016/j.ebiom.2023.104788. Epub 2023 Sep 4. EBioMedicine. 2023. PMID: 37672867 Free PMC article.
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug K. Block J, et al. Among authors: huppa jb. N Engl J Med. 2023 Aug 10;389(6):527-539. doi: 10.1056/NEJMoa2210054. Epub 2023 Jun 21. N Engl J Med. 2023. PMID: 37342957
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity.
Nava Lauson CB, Tiberti S, Corsetto PA, Conte F, Tyagi P, Machwirth M, Ebert S, Loffreda A, Scheller L, Sheta D, Mokhtari Z, Peters T, Raman AT, Greco F, Rizzo AM, Beilhack A, Signore G, Tumino N, Vacca P, McDonnell LA, Raimondi A, Greenberg PD, Huppa JB, Cardaci S, Caruana I, Rodighiero S, Nezi L, Manzo T. Nava Lauson CB, et al. Among authors: huppa jb. Cell Metab. 2023 Apr 4;35(4):633-650.e9. doi: 10.1016/j.cmet.2023.02.013. Epub 2023 Mar 9. Cell Metab. 2023. PMID: 36898381 Free article.
CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer.
Menon AP, Villanueva H, Meraviglia-Crivelli D, van Santen HM, Hellmeier J, Zheleva A, Nonateli F, Peters T, Wachsmann TLA, Hernandez-Rueda M, Huppa JB, Schütz GJ, Sevcsik E, Moreno B, Pastor F. Menon AP, et al. Among authors: huppa jb. Mol Ther Nucleic Acids. 2024 Apr 23;35(2):102198. doi: 10.1016/j.omtn.2024.102198. eCollection 2024 Jun 11. Mol Ther Nucleic Acids. 2024. PMID: 38745854 Free PMC article.
TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation.
Mühlgrabner V, Peters T, Velasco Cárdenas RM, Salzer B, Göhring J, Plach A, Höhrhan M, Perez ID, Goncalves VDR, Farfán JS, Lehner M, Stockinger H, Schamel WW, Schober K, Busch DH, Hudecek M, Dushek O, Minguet S, Platzer R, Huppa JB. Mühlgrabner V, et al. Among authors: huppa jb. Sci Adv. 2024 Sep 6;10(36):eadj4632. doi: 10.1126/sciadv.adj4632. Epub 2024 Sep 4. Sci Adv. 2024. PMID: 39231214 Free PMC article.
CXCR4 has a dual role in improving the efficacy of BCMA-redirected CAR-NK cells in multiple myeloma.
Moles MW, Erdlei H, Menzel L, Massaro M, Fiori A, Bunse M, Schrimpf M, Gerlach K, Gudipati V, Reiser J, Mathavan K, Goodrich JP, Huppa JB, Krönke J, Valamehr B, Höpken UE, Rehm A. Moles MW, et al. Among authors: huppa jb. Front Immunol. 2024 Jun 24;15:1383136. doi: 10.3389/fimmu.2024.1383136. eCollection 2024. Front Immunol. 2024. PMID: 38979422 Free PMC article.
Breakthrough Infections in SARS-CoV-2-Vaccinated Multiple Myeloma Patients Improve Cross-Protection against Omicron Variants.
Wagner A, Garner-Spitzer E, Auer C, Gattinger P, Zwazl I, Platzer R, Orola-Taus M, Pichler P, Amman F, Bergthaler A, Huppa JB, Stockinger H, Zielinski CC, Valenta R, Kundi M, Wiedermann U. Wagner A, et al. Among authors: huppa jb. Vaccines (Basel). 2024 May 9;12(5):518. doi: 10.3390/vaccines12050518. Vaccines (Basel). 2024. PMID: 38793769 Free PMC article.
Measurement of Forces Acting on Single T-Cell Receptors.
Schrangl L, Göhring J, Kellner F, Huppa JB, Schütz GJ. Schrangl L, et al. Among authors: huppa jb. Methods Mol Biol. 2024;2800:147-165. doi: 10.1007/978-1-0716-3834-7_11. Methods Mol Biol. 2024. PMID: 38709483
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.
Andreu-Saumell I, Rodriguez-Garcia A, Mühlgrabner V, Gimenez-Alejandre M, Marzal B, Castellsagué J, Brasó-Maristany F, Calderon H, Angelats L, Colell S, Nuding M, Soria-Castellano M, Barbao P, Prat A, Urbano-Ispizua A, Huppa JB, Guedan S. Andreu-Saumell I, et al. Among authors: huppa jb. Nat Commun. 2024 Apr 26;15(1):3552. doi: 10.1038/s41467-024-47799-z. Nat Commun. 2024. PMID: 38670972 Free PMC article.
76 results