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Page 1
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Among authors: felder cc. Nat Commun. 2023 Sep 6;14(1):5440. doi: 10.1038/s41467-023-41199-5. Nat Commun. 2023. PMID: 37673901 Free PMC article.
Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: felder cc. Nat Chem Biol. 2023 Jul;19(7):805-814. doi: 10.1038/s41589-022-01247-5. Epub 2023 Feb 13. Nat Chem Biol. 2023. PMID: 36782010 Free PMC article.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: felder cc. Nat Chem Biol. 2023 Apr;19(4):529. doi: 10.1038/s41589-023-01297-3. Nat Chem Biol. 2023. PMID: 36879062 Free PMC article. No abstract available.
The Opioid Crisis and the Future of Addiction and Pain Therapeutics.
Coussens NP, Sittampalam GS, Jonson SG, Hall MD, Gorby HE, Tamiz AP, McManus OB, Felder CC, Rasmussen K. Coussens NP, et al. Among authors: felder cc. J Pharmacol Exp Ther. 2019 Nov;371(2):396-408. doi: 10.1124/jpet.119.259408. Epub 2019 Sep 3. J Pharmacol Exp Ther. 2019. PMID: 31481516 Free PMC article. Review.
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
Hollingsworth SA, Kelly B, Valant C, Michaelis JA, Mastromihalis O, Thompson G, Venkatakrishnan AJ, Hertig S, Scammells PJ, Sexton PM, Felder CC, Christopoulos A, Dror RO. Hollingsworth SA, et al. Among authors: felder cc. Nat Commun. 2019 Jul 23;10(1):3289. doi: 10.1038/s41467-019-11062-7. Nat Commun. 2019. PMID: 31337749 Free PMC article.
Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.
Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, Swanson S, Catlow J, Witkin JM, Zwart R, Sher E, Choong KC, Wall TM, Schober D, Felder CC, Kato AS, Bredt DS, Nisenbaum ES. Knopp KL, et al. Among authors: felder cc. J Pharmacol Exp Ther. 2019 Jun;369(3):345-363. doi: 10.1124/jpet.118.250126. Epub 2019 Mar 25. J Pharmacol Exp Ther. 2019. PMID: 30910921
141 results