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Amyloid-β and caspase-1 are indicators of sepsis and organ injury.
Tuckey AN, Brandon A, Eslaamizaad Y, Siddiqui W, Nawaz T, Clarke C, Sutherland E, Williams V, Spadafora D, Barrington RA, Alvarez DF, Mulekar MS, Simmons JD, Fouty BW, Audia JP. Tuckey AN, et al. Among authors: spadafora d. ERJ Open Res. 2024 Feb 26;10(1):00572-2023. doi: 10.1183/23120541.00572-2023. eCollection 2024 Jan. ERJ Open Res. 2024. PMID: 38410714 Free PMC article.
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
Liu L, Malagu K, Haughan AF, Khetarpal V, Stott AJ, Esmieu W, Vater HD, Webster SJ, Van de Poël AJ, Clissold C, Cosgrove B, Sutton B, Spencer JA, Breccia P, Gancia E, Bonomo S, Ladduwahetty T, Lazari O, Patel H, Atton HC, Clifton S, Mota DM, Magnani D, O'Neill A, Stebbeds M, Macabuag N, Todd D, Herva ME, Mitchell P, Visser M, Compte Sancerni S, Grand Moursel L, da Silva M, Kritikou E, Heikkinen TT, Bolkvadze T, Fodale V, Spadafora D, Daldin M, Bresciani A, Mangette JE, Doherty EM, Lee MR, Herbst T, Monteagudo E, Macdonald D, Plotnikov NV, Chambers M, McAllister G, Muňoz-Sanjuan I, Dominguez C. Liu L, et al. Among authors: spadafora d. J Med Chem. 2023 Sep 28;66(18):13205-13246. doi: 10.1021/acs.jmedchem.3c01173. Epub 2023 Sep 15. J Med Chem. 2023. PMID: 37712656
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.
Gwin MS, Alexeyev MF, Geurts AM, Lee JY, Zhou C, Yang XM, Cohen MV, Downey JM, Barrington RA, Spadafora D, Audia JP, Frank DW, Voth S, Pastukh VV, Bell J, Ayers L, Tambe DT, Nelson AR, Balczon R, Lin MT, Stevens T. Gwin MS, et al. Among authors: spadafora d. Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1;325(2):L174-L189. doi: 10.1152/ajplung.00018.2023. Epub 2023 Jun 27. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37366533 Free PMC article.
ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection.
Hardy KS, Tuckey AN, Renema P, Patel M, Al-Mehdi AB, Spadafora D, Schlumpf CA, Barrington RA, Alexeyev MF, Stevens T, Pittet JF, Wagener BM, Simmons JD, Alvarez DF, Audia JP. Hardy KS, et al. Among authors: spadafora d. Toxins (Basel). 2022 Feb 18;14(2):152. doi: 10.3390/toxins14020152. Toxins (Basel). 2022. PMID: 35202178 Free PMC article.
Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: modulation of transmissible cytotoxicity.
Renema P, Kozhukhar N, Pastukh V, Spadafora D, Paudel SS, Tambe DT, Alexeyev M, Frank DW, Stevens T. Renema P, et al. Among authors: spadafora d. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L380-L390. doi: 10.1152/ajplung.00508.2019. Epub 2020 Jun 24. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32579398 Free PMC article.
cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection.
Renema P, Hardy KS, Housley N, Dunbar G, Annamdevula N, Britain A, Spadafora D, Leavesley S, Rich T, Audia JP, Alvarez DF. Renema P, et al. Among authors: spadafora d. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1074-L1083. doi: 10.1152/ajplung.00185.2019. Epub 2020 Mar 18. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32186399 Free PMC article.
23 results