Yang J - Search Results

1

Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation.

Yang J, Pan Y, Zeng X, Liu S, Chen Z, Cheng K. Yang J, et al. Acta Pharm Sin B. 2023 Sep;13(9):3782-3801. doi: 10.1016/j.apsb.2023.05.034. Epub 2023 Jun 1. Acta Pharm Sin B. 2023. PMID: 37719381 Free PMC article.

2

Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy.

Chen Z, Zhang L, Yang J, Zheng L, Hu F, Duan S, Nandakumar KS, Liu S, Yin H, Cheng K. Chen Z, et al. Among authors: yang j. J Med Chem. 2021 Jun 10;64(11):7371-7389. doi: 10.1021/acs.jmedchem.0c02266. Epub 2021 May 24. J Med Chem. 2021. PMID: 34029463

3

Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization.

Yang J, Hu F, Guo C, Liang Y, Song H, Cheng K. Yang J, et al. Bioorg Chem. 2021 Sep;114:105043. doi: 10.1016/j.bioorg.2021.105043. Epub 2021 Jun 1. Bioorg Chem. 2021. PMID: 34120019

4

Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library database.

Chen Z , Cen X , Yang J , Tang X , Cui K , Cheng K . Chen Z , et al. Among authors: yang j. Chem Commun (Camb). 2018 Oct 9;54(81):11411-11414. doi: 10.1039/c8cc06618c. Chem Commun (Camb). 2018. PMID: 30246199

5

Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors.

Chen Z, Cen X, Yang J, Lin Z, Liu M, Cheng K. Chen Z, et al. Among authors: yang j. Eur J Med Chem. 2019 May 1;169:42-52. doi: 10.1016/j.ejmech.2019.02.067. Epub 2019 Mar 1. Eur J Med Chem. 2019. PMID: 30852386

6

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Cen X, Zhu G, Yang J, Yang J, Guo J, Jin J, Nandakumar KS, Yang W, Yin H, Liu S, Cheng K. Cen X, et al. Among authors: yang w, yang j. Adv Sci (Weinh). 2019 Mar 27;6(10):1802042. doi: 10.1002/advs.201802042. eCollection 2019 May 17. Adv Sci (Weinh). 2019. PMID: 31131189 Free PMC article.

7

Design, synthesis and bioactivity evaluation of a series of quinazolinone derivatives as potent PI3Kγ antagonist.

Liang Y, Zheng Y, Yang J, Ke J, Cheng K. Liang Y, et al. Among authors: yang j. Bioorg Med Chem. 2023 Apr 15;84:117261. doi: 10.1016/j.bmc.2023.117261. Epub 2023 Mar 30. Bioorg Med Chem. 2023. PMID: 37011446

8

Autophagy induced by STING, an unnoticed and primordial function of cGAS.

Yang J, Tang X, Nandakumar KS, Cheng K. Yang J, et al. Cell Mol Immunol. 2019 Aug;16(8):683-684. doi: 10.1038/s41423-019-0240-2. Epub 2019 May 29. Cell Mol Immunol. 2019. PMID: 31142798 Free PMC article. No abstract available.

9

Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Yang JJ, Yu WW, Hu LL, Liu WJ, Lin XH, Wang W, Zhang Q, Wang PL, Tang SW, Wang X, Liu M, Lu W, Zhang HK. Yang JJ, et al. J Med Chem. 2020 Jan 23;63(2):569-590. doi: 10.1021/acs.jmedchem.9b01269. Epub 2020 Jan 2. J Med Chem. 2020. PMID: 31855426

10

Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Wang W, He J, Yang J, Zhang C, Cheng Z, Zhang Y, Zhang Q, Wang P, Tang S, Wang X, Liu M, Lu W, Zhang HK. Wang W, et al. Among authors: yang j. J Med Chem. 2022 Jun 9;65(11):7896-7917. doi: 10.1021/acs.jmedchem.2c00448. Epub 2022 May 31. J Med Chem. 2022. PMID: 35640059

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