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SETD2 safeguards the genome against isochromosome formation.
Mason FM, Kounlavong ES, Tebeje AT, Dahiya R, Guess T, Khan A, Vlach L, Norris SR, Lovejoy CA, Dere R, Strahl BD, Ohi R, Ly P, Walker CL, Rathmell WK. Mason FM, et al. Among authors: lovejoy ca. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2303752120. doi: 10.1073/pnas.2303752120. Epub 2023 Sep 18. Proc Natl Acad Sci U S A. 2023. PMID: 37722039 Free PMC article.
Functional genomic screens identify CINP as a genome maintenance protein.
Lovejoy CA, Xu X, Bansbach CE, Glick GG, Zhao R, Ye F, Sirbu BM, Titus LC, Shyr Y, Cortez D. Lovejoy CA, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19304-9. doi: 10.1073/pnas.0909345106. Epub 2009 Nov 4. Proc Natl Acad Sci U S A. 2009. PMID: 19889979 Free PMC article.
SMARCAL1 maintains telomere integrity during DNA replication.
Poole LA, Zhao R, Glick GG, Lovejoy CA, Eischen CM, Cortez D. Poole LA, et al. Among authors: lovejoy ca. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14864-9. doi: 10.1073/pnas.1510750112. Epub 2015 Nov 17. Proc Natl Acad Sci U S A. 2015. PMID: 26578802 Free PMC article.
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D. Lovejoy CA, et al. Mol Cell Biol. 2006 Nov;26(21):7977-90. doi: 10.1128/MCB.00819-06. Epub 2006 Aug 28. Mol Cell Biol. 2006. PMID: 16940174 Free PMC article.
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK; ALT Starr Cancer Consortium. Lovejoy CA, et al. PLoS Genet. 2012;8(7):e1002772. doi: 10.1371/journal.pgen.1002772. Epub 2012 Jul 19. PLoS Genet. 2012. PMID: 22829774 Free PMC article.
Break-induced replication promotes fragile telomere formation.
Yang Z, Takai KK, Lovejoy CA, de Lange T. Yang Z, et al. Among authors: lovejoy ca. Genes Dev. 2020 Oct 1;34(19-20):1392-1405. doi: 10.1101/gad.328575.119. Epub 2020 Sep 3. Genes Dev. 2020. PMID: 32883681 Free PMC article.
26 results