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ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis.
Cell Rep. 2024 Dec 24;43(12):114988. doi: 10.1016/j.celrep.2024.114988. Epub 2024 Nov 21.
Cell Rep. 2024.
PMID: 39579354
Free PMC article.
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.
Miller KD, O'Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, Papp S, Hulse M, Mukha D, Hlavaty SI, Salcido KN, Bertolazzi F, Srikanth YVV, Zhao S, Wellen KE, Shinde RS, Claiborne DT, Kossenkov A, Salvino JM, Schug ZT.
Miller KD, et al. Among authors: pniewski ka.
Nat Cancer. 2023 Oct;4(10):1491-1507. doi: 10.1038/s43018-023-00636-6. Epub 2023 Sep 18.
Nat Cancer. 2023.
PMID: 37723305
Free PMC article.
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