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Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Bodrug T, et al. Among authors: bolhuis dl. Nat Struct Mol Biol. 2023 Nov;30(11):1663-1674. doi: 10.1038/s41594-023-01105-5. Epub 2023 Sep 21. Nat Struct Mol Biol. 2023. PMID: 37735619 Free PMC article.
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. Watson ER, et al. Among authors: bolhuis dl. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26. Proc Natl Acad Sci U S A. 2019. PMID: 31350353 Free PMC article.
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.
Martinez-Chacin RC, Bodrug T, Bolhuis DL, Kedziora KM, Bonacci T, Ordureau A, Gibbs ME, Weissmann F, Qiao R, Grant GD, Cook JG, Peters JM, Wade Harper J, Emanuele MJ, Brown NG. Martinez-Chacin RC, et al. Among authors: bolhuis dl. Nat Struct Mol Biol. 2020 Jun;27(6):550-560. doi: 10.1038/s41594-020-0424-6. Epub 2020 May 11. Nat Struct Mol Biol. 2020. PMID: 32393902 Free PMC article.
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.
Franks JL, Martinez-Chacin RC, Wang X, Tiedemann RL, Bonacci T, Choudhury R, Bolhuis DL, Enrico TP, Mouery RD, Damrauer JS, Yan F, Harrison JS, Major MB, Hoadley KA, Suzuki A, Rothbart SB, Brown NG, Emanuele MJ. Franks JL, et al. Among authors: bolhuis dl. PLoS Biol. 2020 Dec 11;18(12):e3000975. doi: 10.1371/journal.pbio.3000975. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33306668 Free PMC article.
Cryo-EM structure of the plant 26S proteasome.
Kandolf S, Grishkovskaya I, Belačić K, Bolhuis DL, Amann S, Foster B, Imre R, Mechtler K, Schleiffer A, Tagare HD, Zhong ED, Meinhart A, Brown NG, Haselbach D. Kandolf S, et al. Among authors: bolhuis dl. Plant Commun. 2022 May 9;3(3):100310. doi: 10.1016/j.xplc.2022.100310. Epub 2022 Mar 11. Plant Commun. 2022. PMID: 35576154 Free PMC article.
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation.
Chen J, Bolhuis DL, Laggner C, Kong D, Yu L, Wang X, Emanuele MJ, Brown NG, Liu P. Chen J, et al. Among authors: bolhuis dl. Cancers (Basel). 2023 Jan 14;15(2):517. doi: 10.3390/cancers15020517. Cancers (Basel). 2023. PMID: 36672466 Free PMC article.
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
Hodáková Z, Grishkovskaya I, Brunner HL, Bolhuis DL, Belačić K, Schleiffer A, Kotisch H, Brown NG, Haselbach D. Hodáková Z, et al. Among authors: bolhuis dl. EMBO J. 2023 Aug 15;42(16):e113348. doi: 10.15252/embj.2022113348. Epub 2023 Jul 6. EMBO J. 2023. PMID: 37409633 Free PMC article.
20 results