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Myosin-binding protein C forms C-links and stabilizes OFF states of myosin.
Hessel AL, Engels NM, Kuehn M, Nissen D, Sadler RL, Ma W, Irving TC, Linke WA, Harris SP. Hessel AL, et al. Among authors: irving tc. bioRxiv [Preprint]. 2023 Sep 12:2023.09.10.556972. doi: 10.1101/2023.09.10.556972. bioRxiv. 2023. PMID: 37745361 Free PMC article. Preprint.
The distinctive mechanical and structural signatures of residual force enhancement in myofibers.
Hessel AL, Kuehn M, Palmer BM, Nissen D, Mishra D, Joumaa V, Freundt J, Ma W, Nishikawa KC, Irving T, Linke WA. Hessel AL, et al. bioRxiv [Preprint]. 2023 Feb 21:2023.02.19.529125. doi: 10.1101/2023.02.19.529125. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2413883121. doi: 10.1073/pnas.2413883121 PMID: 36865266 Free PMC article. Updated. Preprint.
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension.
Jani V, Aslam MI, Fenwick AJ, Ma W, Gong H, Milburn G, Nissen D, Salazar IC, Hanselman O, Mukherjee M, Halushka MK, Margulies KB, Campbell K, Irving TC, Kass DA, Hsu S. Jani V, et al. Among authors: irving tc. bioRxiv [Preprint]. 2023 Mar 12:2023.03.09.531988. doi: 10.1101/2023.03.09.531988. bioRxiv. 2023. Update in: Circulation. 2023 Jun 20;147(25):1919-1932. doi: 10.1161/CIRCULATIONAHA.123.064717 PMID: 36945606 Free PMC article. Updated. Preprint.
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors.
Ma W, Del Rio CL, Qi L, Prodanovic M, Mijailovich S, Zambataro C, Gong H, Shimkunas R, Gollapudi S, Nag S, Irving TC. Ma W, et al. Among authors: irving tc. bioRxiv [Preprint]. 2023 Aug 28:2023.04.10.536292. doi: 10.1101/2023.04.10.536292. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2314914121. doi: 10.1073/pnas.2314914121 PMID: 37090664 Free PMC article. Updated. Preprint.
The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.
Ma W, Jani VP, Song T, Gao C, Gong H, Sadayappan S, Kass DA, Irving TC. Ma W, et al. Among authors: irving tc. bioRxiv [Preprint]. 2023 Oct 20:2023.10.18.562891. doi: 10.1101/2023.10.18.562891. bioRxiv. 2023. Update in: PNAS Nexus. 2024 Jan 30;3(2):pgae039. doi: 10.1093/pnasnexus/pgae039 PMID: 37904972 Free PMC article. Updated. Preprint.
KBTBD13 is an actin-binding protein that modulates muscle kinetics.
de Winter JM, Molenaar JP, Yuen M, van der Pijl R, Shen S, Conijn S, van de Locht M, Willigenburg M, Bogaards SJ, van Kleef ES, Lassche S, Persson M, Rassier DE, Sztal TE, Ruparelia AA, Oorschot V, Ramm G, Hall TE, Xiong Z, Johnson CN, Li F, Kiss B, Lozano-Vidal N, Boon RA, Marabita M, Nogara L, Blaauw B, Rodenburg RJ, Küsters B, Doorduin J, Beggs AH, Granzier H, Campbell K, Ma W, Irving T, Malfatti E, Romero NB, Bryson-Richardson RJ, van Engelen BG, Voermans NC, Ottenheijm CA. de Winter JM, et al. J Clin Invest. 2024 Feb 1;134(3):e179111. doi: 10.1172/JCI179111. J Clin Invest. 2024. PMID: 38299595 Free PMC article. No abstract available.
145 results