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Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state.
Paryani F, Kwon JS, Ng CW, Madden N, Ofori K, Tang A, Lu H, Li J, Mahajan A, Davidson SM, Basile A, McHugh C, Vonsattel JP, Hickman R, Zody M, Houseman DE, Goldman JE, Yoo AS, Menon V, Al-Dalahmah O. Paryani F, et al. Among authors: menon v. bioRxiv [Preprint]. 2023 Sep 12:2023.09.08.556867. doi: 10.1101/2023.09.08.556867. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 8;15(1):6742. doi: 10.1038/s41467-024-50626-0 PMID: 37745577 Free PMC article. Updated. Preprint.
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Dewan R, Chia R, Ding J, Hickman RA, Stein TD, Abramzon Y, Ahmed S, Sabir MS, Portley MK, Tucci A, Ibáñez K, Shankaracharya FNU, Keagle P, Rossi G, Caroppo P, Tagliavini F, Waldo ML, Johansson PM, Nilsson CF; American Genome Center (TAGC); FALS Sequencing Consortium; Genomics England Research Consortium; International ALS/FTD Genomics Consortium (iAFGC); International FTD Genetics Consortium (IFGC); International LBD Genomics Consortium (iLBDGC); NYGC ALS Consortium; PROSPECT Consortium; Rowe JB, Benussi L, Binetti G, Ghidoni R, Jabbari E, Viollet C, Glass JD, Singleton AB, Silani V, Ross OA, Ryten M, Torkamani A, Tanaka T, Ferrucci L, Resnick SM, Pickering-Brown S, Brady CB, Kowal N, Hardy JA, Van Deerlin V, Vonsattel JP, Harms MB, Morris HR, Ferrari R, Landers JE, Chiò A, Gibbs JR, Dalgard CL, Scholz SW, Traynor BJ. Dewan R, et al. Neuron. 2021 Feb 3;109(3):448-460.e4. doi: 10.1016/j.neuron.2020.11.005. Epub 2020 Nov 26. Neuron. 2021. PMID: 33242422 Free PMC article.
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.
Al-Dalahmah O, Lam M, McInvale JJ, Qu W, Nguyen T, Mun JY, Kwon S, Ifediora N, Mahajan A, Humala N, Winters T, Angeles E, Jakubiak KA, Kühn R, Kim YA, De Rosa MC, Doege CA, Paryani F, Flowers X, Dovas A, Mela A, Lu H, DeTure MA, Vonsattel JP, Wszolek ZK, Dickson DW, Kuhlmann T, Zaehres H, Schöler HR, Sproul AA, Siegelin MD, De Jager PL, Goldman JE, Menon V, Canoll P, Hargus G. Al-Dalahmah O, et al. Among authors: menon v. Cell Stem Cell. 2024 May 2;31(5):676-693.e10. doi: 10.1016/j.stem.2024.03.013. Epub 2024 Apr 15. Cell Stem Cell. 2024. PMID: 38626772 Free article.
Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.
Yang HS, Teng L, Kang D, Menon V, Ge T, Finucane HK, Schultz AP, Properzi M, Klein HU, Chibnik LB, Schneider JA, Bennett DA, Hohman TJ, Mayeux RP, Johnson KA, De Jager PL, Sperling RA. Yang HS, et al. Among authors: menon v. medRxiv [Preprint]. 2023 Jun 5:2023.06.01.23290850. doi: 10.1101/2023.06.01.23290850. medRxiv. 2023. Update in: Nat Commun. 2023 Nov 30;14(1):7659. doi: 10.1038/s41467-023-43132-2 PMID: 37333223 Free PMC article. Updated. Preprint.
Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1.
Lee H, Aylward AJ, Pearse RV, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Klein HU, De Jager PL, Menon V, Young JE, Young-Pearse TL. Lee H, et al. Among authors: menon v. bioRxiv [Preprint]. 2023 Feb 25:2023.02.25.530017. doi: 10.1101/2023.02.25.530017. bioRxiv. 2023. Update in: Cell Rep. 2023 Aug 29;42(8):112994. doi: 10.1016/j.celrep.2023.112994 PMID: 36865313 Free PMC article. Updated. Preprint.
A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.
Zeng L, Fujita M, Gao Z, White CC, Green GS, Habib N, Menon V, Bennett DA, Boyle PA, Klein HU, De Jager PL. Zeng L, et al. Among authors: menon v. medRxiv [Preprint]. 2023 Mar 29:2023.03.27.23286844. doi: 10.1101/2023.03.27.23286844. medRxiv. 2023. Update in: Biol Psychiatry. 2024 Jul 1;96(1):34-43. doi: 10.1016/j.biopsych.2023.12.012 PMID: 37034737 Free PMC article. Updated. Preprint.
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord.
Tuddenham JF, Fujita M, Khairallah A, Harbison C, Flowers XE, Coronas-Samano G, Maniatis S, Daly A, Schneider JA, Teich AF, Vonsattel JPG, Sims PA, Elyaman W, Bradshaw EM, Phatnani H, Shneider N, Bennett DA, De Jager PL, Przedborski S, Menon V, Olah M. Tuddenham JF, et al. Among authors: menon v. bioRxiv [Preprint]. 2024 Nov 14:2024.11.12.623183. doi: 10.1101/2024.11.12.623183. bioRxiv. 2024. PMID: 39605399 Free PMC article. Preprint.
Genome sequence analyses identify novel risk loci for multiple system atrophy.
Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez-Atienzar S, Reho P, Kaivola K, Walton RL, Reynolds RH, Karra R, Sait S, Akcimen F, Diez-Fairen M, Alvarez I, Fanciulli A, Stefanova N, Seppi K, Duerr S, Leys F, Krismer F, Sidoroff V, Zimprich A, Pirker W, Rascol O, Foubert-Samier A, Meissner WG, Tison F, Pavy-Le Traon A, Pellecchia MT, Barone P, Russillo MC, Marín-Lahoz J, Kulisevsky J, Torres S, Mir P, Periñán MT, Proukakis C, Chelban V, Wu L, Goh YY, Parkkinen L, Hu MT, Kobylecki C, Saxon JA, Rollinson S, Garland E, Biaggioni I, Litvan I, Rubio I, Alcalay RN, Kwei KT, Lubbe SJ, Mao Q, Flanagan ME, Castellani RJ, Khurana V, Ndayisaba A, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Moore A, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Kim C, Iba M, Masliah E, Dawson TM, Rosenthal LS, Pantelyat A, Albert MS, Pletnikova O, Troncoso JC, Infante J, Lage C, Sánchez-Juan P, Serrano GE, Beach TG, Pastor P, Morris HR, Albani D, Clarimon J, Wenning GK, Hardy JA, Ryten M, Topol E, Torkamani A, Chiò A, Bennett DA, De Jager PL, Low PA, Singer W, Cheshire WP, Wszolek ZK, Dickson DW, Traynor BJ, Gibbs JR, Dalgard CL, Ross OA, Houlden H, Scholz SW. Chia R, et al. Among authors: menon v. Neuron. 2024 Jul 3;112(13):2142-2156.e5. doi: 10.1016/j.neuron.2024.04.002. Epub 2024 May 2. Neuron. 2024. PMID: 38701790 Free article.
1,999 results