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62 results

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Page 1
Droplet Digital PCR for Oncogenic KMT2A Fusion Detection.
Young AL, Davis HC, Challen GA. Young AL, et al. Among authors: challen ga. J Mol Diagn. 2023 Dec;25(12):898-906. doi: 10.1016/j.jmoldx.2023.09.006. Epub 2023 Oct 7. J Mol Diagn. 2023. PMID: 37813299 Free PMC article.
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression.
Kong T, Laranjeira ABA, Yang K, Fisher DAC, Yu L, Poittevin De La Frégonnière L, Wang AZ, Ruzinova MB, Fowles JS, Fulbright MC, Cox MJ, Celik H, Challen GA, Huang S, Oh ST. Kong T, et al. Among authors: challen ga. Nat Cancer. 2023 Jan;4(1):108-127. doi: 10.1038/s43018-022-00486-8. Epub 2022 Dec 29. Nat Cancer. 2023. PMID: 36581736 Free PMC article.
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia.
Kong T, Laranjeira ABA, Letson CT, Yu L, Lin S, Fowles JS, Fisher DAC, Ng S, Yang W, He F, Youn M, Mark K, Jose AS, Liu J, Kim AB, Cox MJ, Fulbright MC, Jayanthan A, Los G, Rentschler SL, Ding L, Sakamoto KM, Dunn SE, Challen GA, Oh ST. Kong T, et al. Among authors: challen ga. Nat Commun. 2025 Jan 16;16(1):492. doi: 10.1038/s41467-024-55643-7. Nat Commun. 2025. PMID: 39820365
RSK1 dependency in FLT3-ITD acute myeloid leukemia.
Kong T, Laranjeira ABA, Letson CT, Yu L, He F, Jayanthan A, Los G, Dunn SE, Challen GA, Oh ST. Kong T, et al. Among authors: challen ga. Blood Cancer J. 2024 Nov 26;14(1):207. doi: 10.1038/s41408-024-01187-4. Blood Cancer J. 2024. PMID: 39592591 Free PMC article.
DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.
Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Hadzijusufovic E, Chandramouly G, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJ, Valent P, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T. Le BV, et al. Among authors: challen ga. bioRxiv [Preprint]. 2024 Sep 19:2024.09.15.613155. doi: 10.1101/2024.09.15.613155. bioRxiv. 2024. PMID: 39411165 Free PMC article. Preprint.
Spatial Mapping of Hematopoietic Clones in Human Bone Marrow.
Young AL, Davis HC, Cox MJ, Parsons TM, Burkart SC, Bender DE, Sun L, Oh ST, Challen GA. Young AL, et al. Among authors: challen ga. Blood Cancer Discov. 2024 May 1;5(3):153-163. doi: 10.1158/2643-3230.BCD-23-0110. Blood Cancer Discov. 2024. PMID: 38421682 Free PMC article.
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
Issa N, Bjeije H, Wilson ER, Krishnan A, Dunuwille WMB, Parsons TM, Zhang CR, Han W, Young AL, Ren Z, Ge K, Wang ES, Weng AP, Cashen A, Spencer DH, Challen GA. Issa N, et al. Among authors: challen ga. Leukemia. 2023 Apr;37(4):728-740. doi: 10.1038/s41375-023-01853-9. Epub 2023 Feb 17. Leukemia. 2023. PMID: 36797416 Free PMC article.
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