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Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, Hashimoto H, Kawanishi M, Sato M, Yagi T, Fujii N. Punchihewa C, et al. Among authors: fujii n. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1. J Biol Chem. 2012. PMID: 22383522 Free PMC article.
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. Inoue A, et al. Among authors: fujii n. J Biol Chem. 2014 Mar 7;289(10):7109-7120. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28. J Biol Chem. 2014. PMID: 24474685 Free PMC article.
Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry.
Sinha C, Zhang W, Moon CS, Actis M, Yarlagadda S, Arora K, Woodroofe K, Clancy JP, Lin S, Ziady AG, Frizzell R, Fujii N, Naren AP. Sinha C, et al. Among authors: fujii n. Chembiochem. 2015 Sep 21;16(14):2017-22. doi: 10.1002/cbic.201500123. Epub 2015 Aug 11. Chembiochem. 2015. PMID: 26227551 Free PMC article.
2,116 results