Varik V - Search Results

1

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics.

Sakenova N, Cacace E, Orakov A, Huber F, Varik V, Kritikos G, Michiels J, Bork P, Cossart P, Goemans CV, Typas A. Sakenova N, et al. Among authors: varik v. Nat Microbiol. 2024 Dec 2. doi: 10.1038/s41564-024-01857-w. Online ahead of print. Nat Microbiol. 2024. PMID: 39623067

2

Systematic analysis of drug combinations against Gram-positive bacteria.

Cacace E, Kim V, Varik V, Knopp M, Tietgen M, Brauer-Nikonow A, Inecik K, Mateus A, Milanese A, Mårli MT, Mitosch K, Selkrig J, Brochado AR, Kuipers OP, Kjos M, Zeller G, Savitski MM, Göttig S, Huber W, Typas A. Cacace E, et al. Among authors: varik v. Nat Microbiol. 2023 Nov;8(11):2196-2212. doi: 10.1038/s41564-023-01486-9. Epub 2023 Sep 28. Nat Microbiol. 2023. PMID: 37770760 Free PMC article.

3

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.

Kudrin P, Dzhygyr I, Ishiguro K, Beljantseva J, Maksimova E, Oliveira SRA, Varik V, Payoe R, Konevega AL, Tenson T, Suzuki T, Hauryliuk V. Kudrin P, et al. Among authors: varik v. Nucleic Acids Res. 2018 Feb 28;46(4):1973-1983. doi: 10.1093/nar/gky023. Nucleic Acids Res. 2018. PMID: 29390134 Free PMC article.

4

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp.

Varik V, Oliveira SRA, Hauryliuk V, Tenson T. Varik V, et al. Sci Rep. 2017 Sep 8;7(1):11022. doi: 10.1038/s41598-017-10988-6. Sci Rep. 2017. PMID: 28887466 Free PMC article.

5

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor.

Beljantseva J, Kudrin P, Jimmy S, Ehn M, Pohl R, Varik V, Tozawa Y, Shingler V, Tenson T, Rejman D, Hauryliuk V. Beljantseva J, et al. Among authors: varik v. Sci Rep. 2017 Feb 3;7:41839. doi: 10.1038/srep41839. Sci Rep. 2017. PMID: 28157202 Free PMC article.

6

Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams.

Kudrin P, Varik V, Oliveira SR, Beljantseva J, Del Peso Santos T, Dzhygyr I, Rejman D, Cava F, Tenson T, Hauryliuk V. Kudrin P, et al. Among authors: varik v. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02173-16. doi: 10.1128/AAC.02173-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28115345 Free PMC article.

7

Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors.

Andresen L, Varik V, Tozawa Y, Jimmy S, Lindberg S, Tenson T, Hauryliuk V. Andresen L, et al. Among authors: varik v. Sci Rep. 2016 Oct 24;6:35824. doi: 10.1038/srep35824. Sci Rep. 2016. PMID: 27775002 Free PMC article.

8

Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes.

Monteferrante CG, Jirgensons A, Varik V, Hauryliuk V, Goessens WH, Hays JP. Monteferrante CG, et al. Among authors: varik v. Eur J Clin Microbiol Infect Dis. 2016 Nov;35(11):1857-1864. doi: 10.1007/s10096-016-2738-1. Epub 2016 Aug 9. Eur J Clin Microbiol Infect Dis. 2016. PMID: 27506217 Free PMC article.

9

Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli.

Varik V, Oliveira SR, Hauryliuk V, Tenson T. Varik V, et al. Sci Rep. 2016 Feb 29;6:22308. doi: 10.1038/srep22308. Sci Rep. 2016. PMID: 26923949 Free PMC article.

10

Phenotypic heterogeneity enables uropathogenic Escherichia coli to evade killing by antibiotics and serum complement.

Putrinš M, Kogermann K, Lukk E, Lippus M, Varik V, Tenson T. Putrinš M, et al. Among authors: varik v. Infect Immun. 2015 Mar;83(3):1056-67. doi: 10.1128/IAI.02725-14. Epub 2015 Jan 5. Infect Immun. 2015. PMID: 25561706 Free PMC article.

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