Nies AT - Search Results

1

Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation.

Nies AT, König J, Leuthold P, Damme K, Winter S, Haag M, Masuda S, Kruck S, Daniel H, Spanier B, Fromm MF, Bedke J, Inui KI, Schwab M, Schaeffeler E. Nies AT, et al. Pharmacol Res. 2023 Oct;196:106941. doi: 10.1016/j.phrs.2023.106941. Epub 2023 Sep 27. Pharmacol Res. 2023. PMID: 37775020 Free article.

2

Export pumps for anionic conjugates encoded by MRP genes.

Keppler D, Cui Y, König J, Leier I, Nies A. Keppler D, et al. Adv Enzyme Regul. 1999;39:237-46. doi: 10.1016/s0065-2571(98)00015-6. Adv Enzyme Regul. 1999. PMID: 10470375

3

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.

König J, Nies AT, Cui Y, Leier I, Keppler D. König J, et al. Among authors: nies at. Biochim Biophys Acta. 1999 Dec 6;1461(2):377-94. doi: 10.1016/s0005-2736(99)00169-8. Biochim Biophys Acta. 1999. PMID: 10581368 Free article. Review.

4

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.

König J, Cui Y, Nies AT, Keppler D. König J, et al. Among authors: nies at. J Biol Chem. 2000 Jul 28;275(30):23161-8. doi: 10.1074/jbc.M001448200. J Biol Chem. 2000. PMID: 10779507 Free article.

5

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter.

Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J. Michalski C, et al. Among authors: nies at. J Biol Chem. 2002 Nov 8;277(45):43058-63. doi: 10.1074/jbc.M207735200. Epub 2002 Aug 23. J Biol Chem. 2002. PMID: 12196548 Free article.

6

Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.

Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D. Kojima H, et al. Among authors: nies at. J Hepatol. 2003 Nov;39(5):693-702. doi: 10.1016/s0168-8278(03)00410-0. J Hepatol. 2003. PMID: 14568249

7

ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.

Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT. Bronger H, et al. Among authors: nies at. Cancer Res. 2005 Dec 15;65(24):11419-28. doi: 10.1158/0008-5472.CAN-05-1271. Cancer Res. 2005. PMID: 16357150

8

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs.

Nies AT, Schwab M, Keppler D. Nies AT, et al. Expert Opin Drug Metab Toxicol. 2008 May;4(5):545-68. doi: 10.1517/17425255.4.5.545. Expert Opin Drug Metab Toxicol. 2008. PMID: 18484914 Review.

9

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E. Nies AT, et al. Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103. Hepatology. 2009. PMID: 19591196

10

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.

Nies AT, Koepsell H, Damme K, Schwab M. Nies AT, et al. Handb Exp Pharmacol. 2011;(201):105-67. doi: 10.1007/978-3-642-14541-4_3. Handb Exp Pharmacol. 2011. PMID: 21103969 Review.

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