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Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites.
Coelho CH, Marquez S, Tentokam BCN, Berhe AD, Miura K, Long CA, Sagara I, Healy S, Kleinstein SH, Duffy PE. Coelho CH, et al. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551554. doi: 10.1101/2023.08.01.551554. bioRxiv. 2023. Update in: NPJ Vaccines. 2024 Aug 10;9(1):144. doi: 10.1038/s41541-024-00929-6 PMID: 37781572 Free PMC article. Updated. Preprint.
Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice.
Coelho CH, Gazzinelli-Guimaraes PH, Howard J, Barnafo E, Alani NAH, Muratova O, McCormack A, Kelnhofer E, Urban JF Jr, Narum DL, Anderson C, Langhorne J, Nutman TB, Duffy PE. Coelho CH, et al. Vaccine. 2019 Feb 14;37(8):1038-1045. doi: 10.1016/j.vaccine.2019.01.027. Epub 2019 Jan 23. Vaccine. 2019. PMID: 30685251 Free PMC article.
Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing.
Coelho CH, Nadakal ST, Gonzales Hurtado P, Morrison R, Galson JD, Neal J, Wu Y, King CR, Price V, Miura K, Wong-Madden S, Alamou Doritchamou JY, Narum DL, MacDonald NJ, Snow-Smith M, Vignali M, Taylor JJ, Lefranc MP, Trück J, Long CA, Healy SA, Sagara I, Fried M, Duffy PE. Coelho CH, et al. JCI Insight. 2020 Nov 19;5(22):e143471. doi: 10.1172/jci.insight.143471. JCI Insight. 2020. PMID: 33048842 Free PMC article.
Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice.
Healy SA, Anderson C, Swihart BJ, Mwakingwe A, Gabriel EE, Decederfelt H, Hobbs CV, Rausch KM, Zhu D, Muratova O, Herrera R, Scaria PV, MacDonald NJ, Lambert LE, Zaidi I, Coelho CH, Renn JP, Wu Y, Narum DL, Duffy PE. Healy SA, et al. Among authors: coelho ch. J Clin Invest. 2021 Apr 1;131(7):e146221. doi: 10.1172/JCI146221. J Clin Invest. 2021. PMID: 33561016 Free PMC article. Clinical Trial.
41 results