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Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O'Neill J, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Gonzalez MJD, Bennett NR, Venkatesh P, Satoe D, Ahlrichs M, Dobbins C, Yang W, Wang X, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Bernardes GJL, Roybal KT, Greisen P Jr, Li X, Bertozzi C, Baker D. Huang B, et al. Among authors: mout r. bioRxiv [Preprint]. 2023 Sep 20:2023.08.19.553321. doi: 10.1101/2023.08.19.553321. bioRxiv. 2023. PMID: 37781607 Free PMC article. Preprint.
De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity.
Mout R, Bretherton RC, Decarreau J, Lee S, Edman NI, Ahlrichs M, Hsia Y, Sahtoe DD, Ueda G, Gregorio N, Sharma A, Schulman R, DeForest CA, Baker D. Mout R, et al. bioRxiv [Preprint]. 2023 Jun 3:2023.06.02.543449. doi: 10.1101/2023.06.02.543449. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2309457121. doi: 10.1073/pnas.2309457121 PMID: 37398067 Free PMC article. Updated. Preprint.
Designed endocytosis-inducing proteins degrade targets and amplify signals.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O'Neill J, Yi L, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Duran Gonzalez MJ, Bennett NR, Venkatesh P, Ahlrichs M, Dobbins C, Yang W, Wang X, Sahtoe DD, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Roybal KT, Greisen PJ, Li X, Bernardes GJL, Bertozzi CR, Baker D. Huang B, et al. Among authors: mout r. Nature. 2024 Sep 25. doi: 10.1038/s41586-024-07948-2. Online ahead of print. Nature. 2024. PMID: 39322662
Design of multi-scale protein complexes by hierarchical building block fusion.
Hsia Y, Mout R, Sheffler W, Edman NI, Vulovic I, Park YJ, Redler RL, Bick MJ, Bera AK, Courbet A, Kang A, Brunette TJ, Nattermann U, Tsai E, Saleem A, Chow CM, Ekiert D, Bhabha G, Veesler D, Baker D. Hsia Y, et al. Among authors: mout r. Nat Commun. 2021 Apr 16;12(1):2294. doi: 10.1038/s41467-021-22276-z. Nat Commun. 2021. PMID: 33863889 Free PMC article.
In Vivo Editing of Macrophages through Systemic Delivery of CRISPR-Cas9-Ribonucleoprotein-Nanoparticle Nanoassemblies.
Lee YW, Mout R, Luther DC, Liu Y, Castellanos-García L, Burnside AS, Ray M, Tonga GY, Hardie J, Nagaraj H, Das R, Phillips EL, Tay T, Vachet RW, Rotello VM. Lee YW, et al. Among authors: mout r. Adv Ther (Weinh). 2019 Oct;2(10):1900041. doi: 10.1002/adtp.201900041. Epub 2019 Aug 15. Adv Ther (Weinh). 2019. PMID: 34095457 Free PMC article.
Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays.
Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM. Geng Y, et al. Among authors: mout r. Nanomedicine. 2018 Aug;14(6):1931-1939. doi: 10.1016/j.nano.2018.05.009. Epub 2018 May 17. Nanomedicine. 2018. PMID: 29778888 Free PMC article.
CRISPRed Macrophages for Cell-Based Cancer Immunotherapy.
Ray M, Lee YW, Hardie J, Mout R, Yeşilbag Tonga G, Farkas ME, Rotello VM. Ray M, et al. Among authors: mout r. Bioconjug Chem. 2018 Feb 21;29(2):445-450. doi: 10.1021/acs.bioconjchem.7b00768. Epub 2018 Jan 22. Bioconjug Chem. 2018. PMID: 29298051 Free PMC article.
42 results