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Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.
Zhao X, Li Y, Zhang S, Sudwarts A, Zhang H, Kozlova A, Moulton MJ, Goodman LD, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J. Zhao X, et al. Among authors: thinakaran g. medRxiv [Preprint]. 2024 Aug 15:2024.08.14.24312009. doi: 10.1101/2024.08.14.24312009. medRxiv. 2024. PMID: 39185522 Free PMC article. Preprint.
Alzheimer's disease risk allele of PICALM causes detrimental lipid droplets in microglia.
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J. Kozlova A, et al. Among authors: thinakaran g. Res Sq [Preprint]. 2024 May 24:rs.3.rs-4407146. doi: 10.21203/rs.3.rs-4407146/v1. Res Sq. 2024. PMID: 38826437 Free PMC article. Preprint.
Alzheimer's genes in microglia: a risk worth investigating.
Sudwarts A, Thinakaran G. Sudwarts A, et al. Among authors: thinakaran g. Mol Neurodegener. 2023 Nov 20;18(1):90. doi: 10.1186/s13024-023-00679-4. Mol Neurodegener. 2023. PMID: 37986179 Free PMC article. Review.
Correction: Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
De Rossi P, Buggia-Prévot V, Clayton BLL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, Pytel P, Estus S, Thinakaran G. De Rossi P, et al. Among authors: thinakaran g. Mol Neurodegener. 2023 Oct 2;18(1):72. doi: 10.1186/s13024-023-00662-z. Mol Neurodegener. 2023. PMID: 37784204 Free PMC article. No abstract available.
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, Rangaraju S. Sudwarts A, et al. Among authors: thinakaran g. Mol Neurodegener. 2022 May 7;17(1):33. doi: 10.1186/s13024-022-00535-x. Mol Neurodegener. 2022. PMID: 35526014 Free PMC article.
138 results