Manetsch R - Search Results

1

Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases.

Kassu M, Parvatkar PT, Milanes J, Monaghan NP, Kim C, Dowgiallo M, Zhao Y, Asakawa AH, Huang L, Wagner A, Miller B, Carter K, Barrett KF, Tillery LM, Barrett LK, Phan IQ, Subramanian S, Myler PJ, Van Voorhis WC, Leahy JW, Rice CA, Kyle DE, Morris J, Manetsch R. Kassu M, et al. Among authors: manetsch r. ACS Infect Dis. 2023 Nov 10;9(11):2190-2201. doi: 10.1021/acsinfecdis.3c00284. Epub 2023 Oct 11. ACS Infect Dis. 2023. PMID: 37820055 Free PMC article.

2

Probing gorge dimensions of cholinesterases by freeze-frame click chemistry.

Radić Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. Radić Z, et al. Among authors: manetsch r. Chem Biol Interact. 2008 Sep 25;175(1-3):161-5. doi: 10.1016/j.cbi.2008.04.048. Epub 2008 May 8. Chem Biol Interact. 2008. PMID: 18555981 Free PMC article.

3

SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines.

Zhu X, Van Horn KS, Barber MM, Yang S, Wang MZ, Manetsch R, Werbovetz KA. Zhu X, et al. Among authors: manetsch r. Bioorg Med Chem. 2015 Aug 15;23(16):5182-9. doi: 10.1016/j.bmc.2015.02.020. Epub 2015 Feb 18. Bioorg Med Chem. 2015. PMID: 25749014 Free PMC article.

4

Fluorescent properties and resonance energy transfer of 3,4-bis(2,4-difluorophenyl)-maleimide.

Nacheva KP, Maza WA, Myers DZ, Fronczek FR, Larsen RW, Manetsch R. Nacheva KP, et al. Among authors: manetsch r. Org Biomol Chem. 2012 Oct 14;10(38):7840-6. doi: 10.1039/c2ob25981h. Org Biomol Chem. 2012. PMID: 22930038

5

Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling.

Zheng L, Manetsch R, Woggon WD, Baumann U, Reymond JL. Zheng L, et al. Among authors: manetsch r. Bioorg Med Chem. 2005 Feb 15;13(4):1021-9. doi: 10.1016/j.bmc.2004.11.041. Bioorg Med Chem. 2005. PMID: 15670909

6

3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability.

Kumar AB, Tipton JD, Manetsch R. Kumar AB, et al. Among authors: manetsch r. Chem Commun (Camb). 2016 Feb 14;52(13):2729-32. doi: 10.1039/c5cc09518b. Chem Commun (Camb). 2016. PMID: 26758021 Free PMC article.

7

In situ click chemistry: a powerful means for lead discovery.

Sharpless KB, Manetsch R. Sharpless KB, et al. Among authors: manetsch r. Expert Opin Drug Discov. 2006 Nov;1(6):525-38. doi: 10.1517/17460441.1.6.525. Expert Opin Drug Discov. 2006. PMID: 23506064

8

In situ click chemistry: enzyme inhibitors made to their own specifications.

Manetsch R, Krasiński A, Radić Z, Raushel J, Taylor P, Sharpless KB, Kolb HC. Manetsch R, et al. J Am Chem Soc. 2004 Oct 13;126(40):12809-18. doi: 10.1021/ja046382g. J Am Chem Soc. 2004. PMID: 15469276

9

A catalytic antibody against a tocopherol cyclase inhibitor.

Manetsch R, Zheng L, Reymond MT, Woggon WD, Reymond JL. Manetsch R, et al. Chemistry. 2004 May 17;10(10):2487-506. doi: 10.1002/chem.200305629. Chemistry. 2004. PMID: 15146522

10

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. Cross RM, et al. Among authors: manetsch r. J Med Chem. 2010 Oct 14;53(19):7076-94. doi: 10.1021/jm1007903. J Med Chem. 2010. PMID: 20828199

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