Ashani Y - Search Results

1

The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.

Dym O, Aggarwal N, Ashani Y, Leader H, Albeck S, Unger T, Hamer-Rogotner S, Silman I, Tawfik DS, Sussman JL. Dym O, et al. Among authors: ashani y. Acta Crystallogr D Struct Biol. 2023 Nov 1;79(Pt 11):992-1009. doi: 10.1107/S2059798323007672. Epub 2023 Oct 20. Acta Crystallogr D Struct Biol. 2023. PMID: 37860961 Free PMC article.

2

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.

Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS. Ashani Y, et al. Toxicol Lett. 2011 Sep 25;206(1):24-8. doi: 10.1016/j.toxlet.2011.07.017. Epub 2011 Jul 23. Toxicol Lett. 2011. PMID: 21807078 Free PMC article.

3

Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.

Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS. Goldsmith M, et al. Among authors: ashani y. Chem Biol. 2012 Apr 20;19(4):456-66. doi: 10.1016/j.chembiol.2012.01.017. Chem Biol. 2012. PMID: 22520752

4

Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.

Goldsmith M, Eckstein S, Ashani Y, Greisen P Jr, Leader H, Sussman JL, Aggarwal N, Ovchinnikov S, Tawfik DS, Baker D, Thiermann H, Worek F. Goldsmith M, et al. Among authors: ashani y. Arch Toxicol. 2016 Nov;90(11):2711-2724. doi: 10.1007/s00204-015-1626-2. Epub 2015 Nov 26. Arch Toxicol. 2016. PMID: 26612364

5

The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.

Dym O, Song W, Felder C, Roth E, Shnyrov V, Ashani Y, Xu Y, Joosten RP, Weiner L, Sussman JL, Silman I. Dym O, et al. Among authors: ashani y. Protein Sci. 2016 Jun;25(6):1096-114. doi: 10.1002/pro.2923. Epub 2016 Mar 28. Protein Sci. 2016. PMID: 26990888 Free PMC article.

6

Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.

Goldsmith M, Aggarwal N, Ashani Y, Jubran H, Greisen PJ, Ovchinnikov S, Leader H, Baker D, Sussman JL, Goldenzweig A, Fleishman SJ, Tawfik DS. Goldsmith M, et al. Among authors: ashani y. Protein Eng Des Sel. 2017 Apr 1;30(4):333-345. doi: 10.1093/protein/gzx003. Protein Eng Des Sel. 2017. PMID: 28159998

7

Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.

Harel M, Su CT, Frolow F, Ashani Y, Silman I, Sussman JL. Harel M, et al. Among authors: ashani y. J Mol Biol. 1991 Oct 5;221(3):909-18. doi: 10.1016/0022-2836(91)80183-u. J Mol Biol. 1991. PMID: 1942036

8

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.

Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H. Ashani Y, et al. Chem Biol Interact. 2010 Sep 6;187(1-3):362-9. doi: 10.1016/j.cbi.2010.02.039. Epub 2010 Mar 19. Chem Biol Interact. 2010. PMID: 20303930 Free PMC article.

9

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.

Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS. Gupta RD, et al. Among authors: ashani y. Nat Chem Biol. 2011 Feb;7(2):120-5. doi: 10.1038/nchembio.510. Epub 2011 Jan 9. Nat Chem Biol. 2011. PMID: 21217689

10

Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries.

Cherny I, Greisen P Jr, Ashani Y, Khare SD, Oberdorfer G, Leader H, Baker D, Tawfik DS. Cherny I, et al. Among authors: ashani y. ACS Chem Biol. 2013 Nov 15;8(11):2394-403. doi: 10.1021/cb4004892. Epub 2013 Oct 4. ACS Chem Biol. 2013. PMID: 24041203

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