Kosuri S - Search Results

1

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants.

McAfee JC, Lee S, Lee J, Bell JL, Krupa O, Davis J, Insigne K, Bond ML, Zhao N, Boyle AP, Phanstiel DH, Love MI, Stein JL, Ruzicka WB, Davila-Velderrain J, Kosuri S, Won H. McAfee JC, et al. Among authors: kosuri s. Cell Genom. 2023 Sep 15;3(10):100404. doi: 10.1016/j.xgen.2023.100404. eCollection 2023 Oct 11. Cell Genom. 2023. PMID: 37868037 Free PMC article.

2

Dissection of c-AMP Response Element Architecture by Using Genomic and Episomal Massively Parallel Reporter Assays.

Davis JE, Insigne KD, Jones EM, Hastings QA, Boldridge WC, Kosuri S. Davis JE, et al. Among authors: kosuri s. Cell Syst. 2020 Jul 22;11(1):75-85.e7. doi: 10.1016/j.cels.2020.05.011. Epub 2020 Jun 29. Cell Syst. 2020. PMID: 32603702 Free article.

3

Systematic Dissection of Sequence Elements Controlling σ70 Promoters Using a Genomically Encoded Multiplexed Reporter Assay in Escherichia coli.

Urtecho G, Tripp AD, Insigne KD, Kim H, Kosuri S. Urtecho G, et al. Among authors: kosuri s. Biochemistry. 2019 Mar 19;58(11):1539-1551. doi: 10.1021/acs.biochem.7b01069. Epub 2018 Dec 21. Biochemistry. 2019. PMID: 29388765 Free PMC article.

4

A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions.

Chong R, Insigne KD, Yao D, Burghard CP, Wang J, Hsiao YE, Jones EM, Goodman DB, Xiao X, Kosuri S. Chong R, et al. Among authors: kosuri s. Mol Cell. 2019 Jan 3;73(1):183-194.e8. doi: 10.1016/j.molcel.2018.10.037. Epub 2018 Nov 29. Mol Cell. 2019. PMID: 30503770 Free PMC article.

5

Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems.

Yu TC, Liu WL, Brinck MS, Davis JE, Shek J, Bower G, Einav T, Insigne KD, Phillips R, Kosuri S, Urtecho G. Yu TC, et al. Among authors: kosuri s. Nat Commun. 2021 Jan 12;12(1):325. doi: 10.1038/s41467-020-20094-3. Nat Commun. 2021. PMID: 33436562 Free PMC article.

6

Functional regulatory variants implicate distinct transcriptional networks in dementia.

Cooper YA, Teyssier N, Dräger NM, Guo Q, Davis JE, Sattler SM, Yang Z, Patel A, Wu S, Kosuri S, Coppola G, Kampmann M, Geschwind DH. Cooper YA, et al. Among authors: kosuri s. Science. 2022 Aug 19;377(6608):eabi8654. doi: 10.1126/science.abi8654. Epub 2022 Aug 19. Science. 2022. PMID: 35981026

7

Structural and functional characterization of G protein-coupled receptors with deep mutational scanning.

Jones EM, Lubock NB, Venkatakrishnan AJ, Wang J, Tseng AM, Paggi JM, Latorraca NR, Cancilla D, Satyadi M, Davis JE, Babu MM, Dror RO, Kosuri S. Jones EM, et al. Among authors: kosuri s. Elife. 2020 Oct 21;9:e54895. doi: 10.7554/eLife.54895. Elife. 2020. PMID: 33084570 Free PMC article.

8

Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross.

Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW. Renganaath K, et al. Among authors: kosuri s. Elife. 2020 Nov 12;9:e62669. doi: 10.7554/eLife.62669. Elife. 2020. PMID: 33179598 Free PMC article.

9

A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing.

Jones EM, Jajoo R, Cancilla D, Lubock NB, Wang J, Satyadi M, Chong R, de March C, Bloom JS, Matsunami H, Kosuri S. Jones EM, et al. Among authors: kosuri s. Cell Syst. 2019 Mar 27;8(3):254-260.e6. doi: 10.1016/j.cels.2019.02.009. Epub 2019 Mar 20. Cell Syst. 2019. PMID: 30904378 Free PMC article.

10

Metagenomic mining of regulatory elements enables programmable species-selective gene expression.

Johns NI, Gomes ALC, Yim SS, Yang A, Blazejewski T, Smillie CS, Smith MB, Alm EJ, Kosuri S, Wang HH. Johns NI, et al. Among authors: kosuri s. Nat Methods. 2018 May;15(5):323-329. doi: 10.1038/nmeth.4633. Epub 2018 Mar 19. Nat Methods. 2018. PMID: 30052624 Free PMC article.

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