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Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells.
Wang Z, Burigotto M, Ghetti S, Vaillant F, Tan T, Capaldo BD, Palmieri M, Hirokawa Y, Tai L, Simpson DS, Chang C, Huang AS, Lieschke E, Diepstraten ST, Kaloni D, Riffkin C, Huang DCS, Li Wai Suen CSN, Garnham AL, Gibbs P, Visvader JE, Sieber OM, Herold MJ, Fava LL, Kelly GL, Strasser A. Wang Z, et al. Cancer Discov. 2024 Feb 8;14(2):362-379. doi: 10.1158/2159-8290.CD-23-0402. Cancer Discov. 2024. PMID: 37877779 Free PMC article.
Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1.
Aubrey BJ, Brennan MS, Diepstraten ST, Wang Z, Chang C, Herold MJ, Strasser A, Kelly GL. Aubrey BJ, et al. Among authors: wang z. Cell Death Differ. 2022 May;29(5):1074-1076. doi: 10.1038/s41418-022-00946-9. Epub 2022 Jan 28. Cell Death Differ. 2022. PMID: 35091693 Free PMC article. No abstract available.
BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells.
Moujalled D, Southon AG, Saleh E, Brinkmann K, Ke F, Iliopoulos M, Cross RS, Jenkins MR, Nhu D, Wang Z, Shi MX, Kluck RM, Lessene G, Grabow S, Bush AI, Strasser A. Moujalled D, et al. Among authors: wang z. Cell Death Differ. 2022 Jul;29(7):1335-1348. doi: 10.1038/s41418-022-00977-2. Epub 2022 Mar 24. Cell Death Differ. 2022. PMID: 35332309 Free PMC article.
Should mutant TP53 be targeted for cancer therapy?
Wang Z, Strasser A, Kelly GL. Wang Z, et al. Cell Death Differ. 2022 May;29(5):911-920. doi: 10.1038/s41418-022-00962-9. Epub 2022 Mar 24. Cell Death Differ. 2022. PMID: 35332311 Free PMC article. Review.
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Cell Death Differ. 2023 Apr;30(4):1033-1046. doi: 10.1038/s41418-023-01122-3. Epub 2023 Feb 4. Cell Death Differ. 2023. PMID: 36739334 Free PMC article.
Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Cell Death Differ. 2023 Apr;30(4):1096. doi: 10.1038/s41418-023-01137-w. Cell Death Differ. 2023. PMID: 36828917 Free PMC article. No abstract available.
Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.
La Marca JE, Aubrey BJ, Yang B, Chang C, Wang Z, Kueh A, Tai L, Wilcox S, Milla L, Heinzel S, Vremec D, Whelan L, König C, Kaloni D, Voss AK, Strasser A, Diepstraten ST, Herold MJ, Kelly GL. La Marca JE, et al. Among authors: wang z. Cell Death Differ. 2024 Feb;31(2):150-158. doi: 10.1038/s41418-023-01249-3. Epub 2023 Dec 14. Cell Death Differ. 2024. PMID: 38097622 Free PMC article.
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