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Discovery of VIP236, an αvβ3-Targeted Small-Molecule-Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors.
Lerchen HG, Stelte-Ludwig B, Heroult M, Zubov D, Gericke KM, Wong H, Frigault MM, Johnson AJ, Izumi R, Hamdy A. Lerchen HG, et al. Among authors: johnson aj. Cancers (Basel). 2023 Sep 1;15(17):4381. doi: 10.3390/cancers15174381. Cancers (Basel). 2023. PMID: 37686656 Free PMC article.
Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment.
Rebstock AS, Wiedmann M, Stelte-Ludwig B, Wong H, Johnson AJ, Izumi R, Hamdy A, Lerchen HG. Rebstock AS, et al. Among authors: johnson aj. Front Pharmacol. 2024 Mar 1;15:1358393. doi: 10.3389/fphar.2024.1358393. eCollection 2024. Front Pharmacol. 2024. PMID: 38495100 Free PMC article.
High-Potency Prenatal Cannabis Exposure and Birth Outcome Measures.
Kleinhans NM, Johnson AJ, Larsen SF, Berkelhamer SK, Larimer ME, Dager SR. Kleinhans NM, et al. Among authors: johnson aj. Children (Basel). 2024 Nov 26;11(12):1436. doi: 10.3390/children11121436. Children (Basel). 2024. PMID: 39767866 Free PMC article.
Sugar-rich foods exacerbate antibiotic-induced microbiome injury.
Dai A, Adintori PA, Funnell T, Jogia WP, Fei T, Waters NR, Rangesa M, Ballweg A, Gipson B, Raj S, Hayase E, Markey KA, Burgos da Silva M, Miltiadous O, Brambilla CZ, Buchan ML, Peets T, Gradissimo A, Smith N, Katsamakis Z, Warren A, Amoretti LA, Duan C, Zhang C, Matheis F, Sullivan AP, Slingerland JB, Clurman A, Brereton DG, Giardina PA, Gomes ALC, Johnson AJ, Knights D, Jenq RR, Perales MA, Giralt SA, Schluter J, van den Brink MRM, Peled J. Dai A, et al. Among authors: johnson aj. bioRxiv [Preprint]. 2024 Oct 14:2024.10.14.617881. doi: 10.1101/2024.10.14.617881. bioRxiv. 2024. PMID: 39463943 Free PMC article. Preprint.
919 results