Fernandez MA - Search Results

1

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.

Aron L, Qiu C, Ngian ZK, Liang M, Drake D, Choi J, Fernandez MA, Roche P, Bunting EL, Lacey EK, Hamplova SE, Yuan M, Wolfe MS, Bennett DA, Lee EA, Yankner BA. Aron L, et al. Among authors: fernandez ma. Nat Commun. 2023 Nov 2;14(1):7030. doi: 10.1038/s41467-023-42704-6. Nat Commun. 2023. PMID: 37919281 Free PMC article.

2

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.

Fernandez MA, Klutkowski JA, Freret T, Wolfe MS. Fernandez MA, et al. J Biol Chem. 2014 Nov 7;289(45):31043-52. doi: 10.1074/jbc.M114.581165. Epub 2014 Sep 19. J Biol Chem. 2014. PMID: 25239621 Free PMC article.

3

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS. Quintero-Monzon O, et al. Among authors: fernandez ma. Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30. Biochemistry. 2011. PMID: 21919498 Free PMC article.

4

Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.

Fernandez MA, Biette KM, Dolios G, Seth D, Wang R, Wolfe MS. Fernandez MA, et al. Biochemistry. 2016 Oct 11;55(40):5675-5688. doi: 10.1021/acs.biochem.6b00718. Epub 2016 Sep 30. Biochemistry. 2016. PMID: 27649271 Free PMC article.

5

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Muratore CR, et al. Among authors: fernandez ma. Stem Cell Reports. 2017 Dec 12;9(6):1868-1884. doi: 10.1016/j.stemcr.2017.10.015. Epub 2017 Nov 16. Stem Cell Reports. 2017. PMID: 29153990 Free PMC article.

6

Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage.

Williamson RL, Laulagnier K, Miranda AM, Fernandez MA, Wolfe MS, Sadoul R, Di Paolo G. Williamson RL, et al. Among authors: fernandez ma. J Biol Chem. 2017 Dec 1;292(48):19873-19889. doi: 10.1074/jbc.M117.818138. Epub 2017 Oct 11. J Biol Chem. 2017. PMID: 29021256 Free PMC article.

7

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.

Lagomarsino VN, Pearse RV 2nd, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL. Lagomarsino VN, et al. Among authors: fernandez ma. Neuron. 2021 Nov 3;109(21):3402-3420.e9. doi: 10.1016/j.neuron.2021.08.003. Epub 2021 Sep 1. Neuron. 2021. PMID: 34473944 Free PMC article.

8

Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain.

Lee Y, Miller MR, Fernandez MA, Berg EL, Prada AM, Ouyang Q, Schmidt M, Silverman JL, Young-Pearse TL, Morrow EM. Lee Y, et al. Among authors: fernandez ma. Brain. 2022 Sep 14;145(9):3187-3202. doi: 10.1093/brain/awab467. Brain. 2022. PMID: 34928329 Free PMC article.

9

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons.

Fernandez MA, Bah F, Ma L, Lee Y, Schmidt M, Welch E, Morrow EM, Young-Pearse TL. Fernandez MA, et al. Among authors: ma l. Stem Cell Reports. 2022 Sep 13;17(9):2111-2126. doi: 10.1016/j.stemcr.2022.08.001. Epub 2022 Sep 1. Stem Cell Reports. 2022. PMID: 36055242 Free PMC article.

10

Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study.

Latorre-Millán M, Rodríguez Del Águila MM, Clusa L, Mazagatos C, Larrauri A, Fernández MA, Rezusta A, Milagro AM. Latorre-Millán M, et al. Among authors: fernandez ma. Viruses. 2024 Oct 30;16(11):1705. doi: 10.3390/v16111705. Viruses. 2024. PMID: 39599820 Free PMC article.

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