Eadsforth TC - Search Results

1

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.

Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M, Post JM, Lopez-Román EM, Engelhart CA, Lukac I, Zuccotto F, Epemolu O, Boshoff HIM, Schnappinger D, Walpole C, Gilbert IH, Read KD, Wyatt PG, Baragaña B. Green SR, et al. Among authors: eadsforth tc. J Med Chem. 2023 Nov 23;66(22):15380-15408. doi: 10.1021/acs.jmedchem.3c01514. Epub 2023 Nov 10. J Med Chem. 2023. PMID: 37948640 Free PMC article.

2

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.

Eadsforth TC, Pinto A, Luciani R, Tamborini L, Cullia G, De Micheli C, Marinelli L, Cosconati S, Novellino E, Lo Presti L, Cordeiro da Silva A, Conti P, Hunter WN, Costi MP. Eadsforth TC, et al. J Med Chem. 2015 Oct 22;58(20):7938-48. doi: 10.1021/acs.jmedchem.5b00687. Epub 2015 Sep 16. J Med Chem. 2015. PMID: 26322631 Free PMC article.

3

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening.

Prakash O, Führing J, Post J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R, Routier FH. Prakash O, et al. Among authors: eadsforth tc. Molecules. 2019 Mar 12;24(5):996. doi: 10.3390/molecules24050996. Molecules. 2019. PMID: 30871023 Free PMC article.

4

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.

Eadsforth TC, Torrie LS, Rowland P, Edgar EV, MacLean LM, Paterson C, Robinson DA, Shepherd SM, Thomas J, Thomas MG, Gray DW, Postis VLG, De Rycker M. Eadsforth TC, et al. J Biol Chem. 2024 Dec 9;301(1):108049. doi: 10.1016/j.jbc.2024.108049. Online ahead of print. J Biol Chem. 2024. PMID: 39638245 Free article.

5

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate.

Morgan RE, Batot GO, Dement JM, Rao VA, Eadsforth TC, Hunter WN. Morgan RE, et al. Among authors: eadsforth tc. BMC Struct Biol. 2011 May 9;11:21. doi: 10.1186/1472-6807-11-21. BMC Struct Biol. 2011. PMID: 21554707 Free PMC article.

6

Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target.

Eadsforth TC, Gardiner M, Maluf FV, McElroy S, James D, Frearson J, Gray D, Hunter WN. Eadsforth TC, et al. PLoS One. 2012;7(4):e35973. doi: 10.1371/journal.pone.0035973. Epub 2012 Apr 25. PLoS One. 2012. PMID: 22558288 Free PMC article.

7

The role of Co²+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols.

Rimsa V, Eadsforth T, Hunter WN. Rimsa V, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):442-5. doi: 10.1107/S1744309111005835. Epub 2011 Mar 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21505236 Free PMC article.

8

Acinetobacter baumannii FolD ligand complexes --potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571.

Eadsforth TC, Maluf FV, Hunter WN. Eadsforth TC, et al. FEBS J. 2012 Dec;279(23):4350-60. doi: 10.1111/febs.12025. Epub 2012 Nov 5. FEBS J. 2012. PMID: 23050773 Free PMC article.

9

Structure of the SCAN domain of human paternally expressed gene 3 protein.

Rimsa V, Eadsforth TC, Hunter WN. Rimsa V, et al. Among authors: eadsforth tc. PLoS One. 2013 Jul 23;8(7):e69538. doi: 10.1371/journal.pone.0069538. Print 2013. PLoS One. 2013. PMID: 23936039 Free PMC article.

10

Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide.

Bisson C, Britton KL, Sedelnikova SE, Rodgers HF, Eadsforth TC, Viner RC, Hawkes TR, Baker PJ, Rice DW. Bisson C, et al. Among authors: eadsforth tc. Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13485-13489. doi: 10.1002/anie.201607185. Epub 2016 Sep 26. Angew Chem Int Ed Engl. 2016. PMID: 27717128 Free PMC article.

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