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Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy.
Liu R, Li X, Ma H, Yang Q, Shang Q, Song L, Zheng Z, Zhang S, Pan Y, Huang P, Fang J, Li Y, Liu Z, Cao L, Feng C, Gong Z, Chen Y, Wang Y, Melino G, Shao C, Shi Y. Liu R, et al. Among authors: fang j. Free Radic Biol Med. 2020 Dec;161:339-350. doi: 10.1016/j.freeradbiomed.2020.10.029. Epub 2020 Oct 24. Free Radic Biol Med. 2020. PMID: 33122005 Free article.
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