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Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation.
Greene NP, Nilsson MI, Washington TA, Lee DE, Brown LA, Papineau AM, Shimkus KL, Greene ES, Crouse SF, Fluckey JD. Greene NP, et al. Among authors: washington ta. Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E503-11. doi: 10.1152/ajpendo.00671.2013. Epub 2014 Jan 7. Am J Physiol Endocrinol Metab. 2014. PMID: 24398401 Free article.
PGC-1α4 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury.
Brown JL, Rosa-Caldwell ME, Lee DE, Brown LA, Perry RA, Shimkus KL, Blackwell TA, Fluckey JD, Carson JA, Dridi S, Washington TA, Greene NP. Brown JL, et al. Among authors: washington ta. Acta Physiol (Oxf). 2017 Jun;220(2):275-288. doi: 10.1111/apha.12826. Epub 2016 Nov 25. Acta Physiol (Oxf). 2017. PMID: 27809412
93 results