Zhang H - Search Results

1

A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology.

Liu PW, Zhang H, Werley CA, Pichler M, Ryan SJ, Lewarch CL, Jacques J, Grooms J, Ferrante J, Li G, Zhang D, Bremmer N, Barnett A, Chantre R, Elder AE, Cohen AE, Williams LA, Dempsey GT, McManus OB. Liu PW, et al. Among authors: zhang d, zhang h. Pain. 2024 Apr 1;165(4):922-940. doi: 10.1097/j.pain.0000000000003090. Epub 2023 Nov 14. Pain. 2024. PMID: 37963235

2

Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels.

Zhang H, Reichert E, Cohen AE. Zhang H, et al. Elife. 2016 May 24;5:e15202. doi: 10.7554/eLife.15202. Elife. 2016. PMID: 27215841 Free PMC article.

3

Optogenetic Approaches to Drug Discovery in Neuroscience and Beyond.

Zhang H, Cohen AE. Zhang H, et al. Trends Biotechnol. 2017 Jul;35(7):625-639. doi: 10.1016/j.tibtech.2017.04.002. Epub 2017 May 25. Trends Biotechnol. 2017. PMID: 28552428 Free PMC article. Review.

4

Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na_V1.7 Inhibitors.

Zhang H, Moyer BD, Yu V, McGivern JG, Jarosh M, Werley CA, Hecht VC, Babcock RJ, Dong K, Dempsey GT, McManus OB, Hempel CM. Zhang H, et al. SLAS Discov. 2020 Jun;25(5):434-446. doi: 10.1177/2472555220914532. Epub 2020 Apr 15. SLAS Discov. 2020. PMID: 32292096 Free article.

5

Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells.

Borja GB, Zhang H, Harwood BN, Jacques J, Grooms J, Chantre RO, Zhang D, Barnett A, Werley CA, Lu Y, Nagle SF, McManus OB, Dempsey GT. Borja GB, et al. Among authors: zhang d, zhang h. Front Mol Neurosci. 2022 Jul 4;15:896320. doi: 10.3389/fnmol.2022.896320. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35860501 Free PMC article.

6

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.

Kiskinis E, Kralj JM, Zou P, Weinstein EN, Zhang H, Tsioras K, Wiskow O, Ortega JA, Eggan K, Cohen AE. Kiskinis E, et al. Among authors: zhang h. Stem Cell Reports. 2018 Jun 5;10(6):1991-2004. doi: 10.1016/j.stemcr.2018.04.020. Epub 2018 May 17. Stem Cell Reports. 2018. PMID: 29779896 Free PMC article.

7

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.

Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz KL, Li M. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. doi: 10.1073/pnas.1205266109. Epub 2012 Jun 28. Proc Natl Acad Sci U S A. 2012. PMID: 22745159 Free PMC article.

8

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.

Yu H, Lin Z, Mattmann ME, Zou B, Terrenoire C, Zhang H, Wu M, McManus OB, Kass RS, Lindsley CW, Hopkins CR, Li M. Yu H, et al. Among authors: zhang h. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8732-7. doi: 10.1073/pnas.1300684110. Epub 2013 May 6. Proc Natl Acad Sci U S A. 2013. PMID: 23650380 Free PMC article.

9

Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons.

Fan L, Guan X, Wang W, Zhao JY, Zhang H, Tiwari V, Hoffman PN, Li M, Tao YX. Fan L, et al. Among authors: zhang h. Mol Pain. 2014 Jan 29;10:8. doi: 10.1186/1744-8069-10-8. Mol Pain. 2014. PMID: 24472174 Free PMC article.

10

GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression.

Shen K, Zhou H, Zuo Q, Gu Y, Cheng J, Yan K, Zhang H, Song H, Liang W, Zhou J, Liu J, Liu F, Zhai C, Fan W. Shen K, et al. Among authors: zhang h. Nat Commun. 2024 Dec 30;15(1):10923. doi: 10.1038/s41467-024-55335-2. Nat Commun. 2024. PMID: 39738099 Free article.

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