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TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models.
Dominguez SL, Laufer BI, Ghosh AS, Li Q, Ruggeri G, Emani MR, Phu L, Friedman BA, Sandoval W, Rose CM, Ngu H, Foreman O, Reichelt M, Juste Y, Lalehzadeh G, Hansen D, Nymark H, Mellal D, Gylling H, Kiełpiński ŁJ, Chih B, Bingol B, Hoogenraad CC, Meilandt WJ, Easton A. Dominguez SL, et al. Among authors: hoogenraad cc. iScience. 2023 Oct 29;26(11):108362. doi: 10.1016/j.isci.2023.108362. eCollection 2023 Nov 17. iScience. 2023. PMID: 37965143 Free PMC article.
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.
Byrnes AE, Dominguez SL, Yen CW, Laufer BI, Foreman O, Reichelt M, Lin H, Sagolla M, Hötzel K, Ngu H, Soendergaard C, Estevez A, Lin HC, Goyon A, Bian J, Lin J, Hinz FI, Friedman BA, Easton A, Hoogenraad CC. Byrnes AE, et al. Among authors: hoogenraad cc. Mol Ther Nucleic Acids. 2023 May 9;32:773-793. doi: 10.1016/j.omtn.2023.05.005. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37346977 Free PMC article.
A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity.
Byrnes AE, Roudnicky F, Gogineni A, Soung AL, Xiong M, Hayne M, Heaster-Ford T, Shatz-Binder W, Dominguez SL, Imperio J, Gierke S, Roberts J, Guo J, Ghosh S, Yu C, Roose-Girma M, Elstrott J, Easton A, Hoogenraad CC. Byrnes AE, et al. Among authors: hoogenraad cc. Cell Rep Methods. 2024 Jan 22;4(1):100673. doi: 10.1016/j.crmeth.2023.100673. Epub 2024 Jan 2. Cell Rep Methods. 2024. PMID: 38171361 Free PMC article.
Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons.
Hinz FI, Villegas CLM, Roberts JT, Yao H, Gaddam S, Delwig A, Green SA, Fredrickson C, Adrian M, Asuncion RR, Cheung TK, Hayne M, Hackos DH, Rose CM, Richmond D, Hoogenraad CC. Hinz FI, et al. Among authors: hoogenraad cc. J Neurosci. 2024 Jun 12;44(24):e2424232024. doi: 10.1523/JNEUROSCI.2424-23.2024. J Neurosci. 2024. PMID: 38692735 Free PMC article.
Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation.
Shan X, Zhang A, Rezzonico MG, Tsai MC, Sanchez-Priego C, Zhang Y, Chen MB, Choi M, Andrade López JM, Phu L, Cramer AL, Zhang Q, Pattison JM, Rose CM, Hoogenraad CC, Jeong CG. Shan X, et al. Among authors: hoogenraad cc. Cell Rep Methods. 2024 Sep 16;4(9):100858. doi: 10.1016/j.crmeth.2024.100858. Epub 2024 Sep 9. Cell Rep Methods. 2024. PMID: 39255791 Free PMC article.
Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology.
Schauer SP, Toth B, Lee J, Honigberg LA, Ramakrishnan V, Jiang J, Kollmorgen G, Bayfield A, Wild N, Hoffman J, Ceniceros R, Dolton M, Bohórquez SMS, Hoogenraad CC, Wildsmith KR, Teng E, Monteiro C, Anania V, Yeh FL. Schauer SP, et al. Among authors: hoogenraad cc. Alzheimers Dement. 2024 Dec;20(12):8855-8866. doi: 10.1002/alz.14346. Epub 2024 Nov 8. Alzheimers Dement. 2024. PMID: 39513754 Free PMC article. Clinical Trial.
Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions.
Koppers M, Özkan N, Nguyen HH, Jurriens D, McCaughey J, Nguyen DTM, Li CH, Stucchi R, Altelaar M, MacGillavry HD, Kapitein LC, Hoogenraad CC, Farías GG. Koppers M, et al. Among authors: hoogenraad cc. Dev Cell. 2024 Aug 19;59(16):2053-2068.e9. doi: 10.1016/j.devcel.2024.05.005. Epub 2024 May 29. Dev Cell. 2024. PMID: 38815583 Free PMC article.
Sodium channel endocytosis drives axon initial segment plasticity.
Fréal A, Jamann N, Ten Bos J, Jansen J, Petersen N, Ligthart T, Hoogenraad CC, Kole MHP. Fréal A, et al. Among authors: hoogenraad cc. Sci Adv. 2023 Sep 15;9(37):eadf3885. doi: 10.1126/sciadv.adf3885. Epub 2023 Sep 15. Sci Adv. 2023. PMID: 37713493 Free PMC article.
234 results