Dötsch V - Search Results

1

Efficient determination of the accessible conformation space of multi-domain complexes based on EPR PELDOR data.

Kazemi S, Lopata A, Kniss A, Pluska L, Güntert P, Sommer T, Prisner TF, Collauto A, Dötsch V. Kazemi S, et al. Among authors: dotsch v. J Biomol NMR. 2023 Dec;77(5-6):261-269. doi: 10.1007/s10858-023-00426-3. Epub 2023 Nov 15. J Biomol NMR. 2023. PMID: 37966668 Free PMC article.

2

Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α.

Lambert M, Gebel J, Trejtnar C, Wesch N, Bozkurt S, Adrian-Allgood M, Löhr F, Münch C, Dötsch V. Lambert M, et al. Among authors: dotsch v. Sci Rep. 2023 Sep 30;13(1):16423. doi: 10.1038/s41598-023-43515-x. Sci Rep. 2023. PMID: 37777570 Free PMC article.

3

ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection.

Smirnov A, Magri A, Lotz R, Han X, Yin C, Harris M, Osterburg C, Dötsch V, McKeating JA, Lu X. Smirnov A, et al. Among authors: dotsch v. J Gen Virol. 2023 Sep;104(9):10.1099/jgv.0.001895. doi: 10.1099/jgv.0.001895. J Gen Virol. 2023. PMID: 37750869 Free PMC article.

4

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant.

Mende H, Khatri A, Lange C, Poveda-Cuevas SA, Tascher G, Covarrubias-Pinto A, Löhr F, Koschade SE, Dikic I, Münch C, Bremm A, Brunetti L, Brandts CH, Uckelmann H, Dötsch V, Rogov VV, Bhaskara RM, Müller S. Mende H, et al. Among authors: dotsch v. Cell Rep. 2023 Dec 26;42(12):113484. doi: 10.1016/j.celrep.2023.113484. Epub 2023 Nov 22. Cell Rep. 2023. PMID: 37999976 Free article.

5

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation.

Wolf K, Kosinski J, Gibson TJ, Wesch N, Dötsch V, Genuardi M, Cordisco EL, Zeuzem S, Brieger A, Plotz G. Wolf K, et al. Among authors: dotsch v. Nucleic Acids Res. 2023 Jul 7;51(12):6307-6320. doi: 10.1093/nar/gkad418. Nucleic Acids Res. 2023. PMID: 37224528 Free PMC article.

6

Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73.

Li D, Kok CYL, Wang C, Ray D, Osterburg S, Dötsch V, Ghosh S, Sabapathy K. Li D, et al. Among authors: dotsch v. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2318591121. doi: 10.1073/pnas.2318591121. Epub 2024 May 13. Proc Natl Acad Sci U S A. 2024. PMID: 38739802 Free PMC article.

7

DARPin-induced reactivation of p53 in HPV-positive cells.

Münick P, Strubel A, Balourdas DI, Funk JS, Mernberger M, Osterburg C, Dreier B, Schaefer JV, Tuppi M, Yüksel B, Schäfer B, Knapp S, Plückthun A, Stiewe T, Joerger AC, Dötsch V. Münick P, et al. Among authors: dotsch v. Nat Struct Mol Biol. 2025 Jan 9. doi: 10.1038/s41594-024-01456-7. Online ahead of print. Nat Struct Mol Biol. 2025. PMID: 39789211

8

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro.

Lotz R, Osterburg C, Chaikuad A, Weber S, Akutsu M, Machel AC, Beyer U, Gebel J, Löhr F, Knapp S, Dobbelstein M, Lu X, Dötsch V. Lotz R, et al. Among authors: dotsch v. Cell Death Dis. 2025 Jan 6;16(1):4. doi: 10.1038/s41419-024-07320-2. Cell Death Dis. 2025. PMID: 39762243 Free PMC article.

9

Cardiocutaneous syndrome is caused by aggregation of iASPP mutants.

Lotz R, Osterburg C, Schäfer B, Lu X, Dötsch V. Lotz R, et al. Among authors: dotsch v. Cell Death Discov. 2024 Dec 18;10(1):497. doi: 10.1038/s41420-024-02265-z. Cell Death Discov. 2024. PMID: 39695191 Free PMC article.

10

DARPins as a novel tool to detect and degrade p73.

Münick P, Zielinski J, Strubel A, Gutfreund N, Dreier B, Schaefer JV, Schäfer B, Gebel J, Osterburg C, Chaikuad A, Knapp S, Plückthun A, Dötsch V. Münick P, et al. Among authors: dotsch v. Cell Death Dis. 2024 Dec 18;15(12):909. doi: 10.1038/s41419-024-07304-2. Cell Death Dis. 2024. PMID: 39695090 Free PMC article.

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