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Discovery of the First-in-Class Inhibitors of Hypoxia Up-Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation.
Angew Chem Int Ed Engl. 2024 Apr 2;63(14):e202319157. doi: 10.1002/anie.202319157. Epub 2024 Feb 26.
Angew Chem Int Ed Engl. 2024.
PMID: 38339863
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.
Sandler SE, Horne RI, Rocchetti S, Novak R, Hsu NS, Castellana Cruz M, Faidon Brotzakis Z, Gregory RC, Chia S, Bernardes GJL, Keyser UF, Vendruscolo M.
Sandler SE, et al. Among authors: faidon brotzakis z.
J Am Chem Soc. 2023 Nov 29;145(47):25776-25788. doi: 10.1021/jacs.3c09335. Epub 2023 Nov 16.
J Am Chem Soc. 2023.
PMID: 37972287
Free PMC article.
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Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy.
Faidon Brotzakis Z, Löhr T, Truong S, Hoff S, Bonomi M, Vendruscolo M.
Faidon Brotzakis Z, et al.
Biochemistry. 2023 Aug 15;62(16):2407-2416. doi: 10.1021/acs.biochem.3c00010. Epub 2023 Jul 21.
Biochemistry. 2023.
PMID: 37477459
Free PMC article.
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Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.
Chia S, Faidon Brotzakis Z, Horne RI, Possenti A, Mannini B, Cataldi R, Nowinska M, Staats R, Linse S, Knowles TPJ, Habchi J, Vendruscolo M.
Chia S, et al. Among authors: faidon brotzakis z.
Mol Pharm. 2023 Jan 2;20(1):183-193. doi: 10.1021/acs.molpharmaceut.2c00548. Epub 2022 Nov 14.
Mol Pharm. 2023.
PMID: 36374974
Free PMC article.
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