Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.
Peng HM, Morishima Y, Pratt WB, Osawa Y.
Peng HM, et al. Among authors: morishima y.
J Biol Chem. 2012 Jan 6;287(2):1556-65. doi: 10.1074/jbc.M111.323295. Epub 2011 Nov 28.
J Biol Chem. 2012.
PMID: 22128174
Free PMC article.
Like other nitric-oxide synthase (NOS) enzymes, neuronal NOS (nNOS) turnover and activity are regulated by the Hsp90/Hsp70-based chaperone machinery, which regulates signaling proteins by modulating ligand binding clefts (Pratt, W. B., Morishima, Y., and Osawa, Y …
Like other nitric-oxide synthase (NOS) enzymes, neuronal NOS (nNOS) turnover and activity are regulated by the Hsp90/Hsp70-based chaperone m …