Saha LK - Search Results

1

The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.

Saha S, Huang SN, Yang X, Saha LK, Sun Y, Khandagale P, Jenkins LM, Pommier Y. Saha S, et al. Among authors: saha lk. Nat Commun. 2023 Nov 18;14(1):7524. doi: 10.1038/s41467-023-43151-z. Nat Commun. 2023. PMID: 37980342 Free PMC article.

2

UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks.

Akagawa R, Trinh HT, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H. Akagawa R, et al. Among authors: saha lk. iScience. 2020 Apr 24;23(4):101027. doi: 10.1016/j.isci.2020.101027. Epub 2020 Mar 31. iScience. 2020. PMID: 32283528 Free PMC article.

3

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.

Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S. Saha LK, et al. Environ Mol Mutagen. 2018 Jul;59(6):529-538. doi: 10.1002/em.22201. Epub 2018 May 15. Environ Mol Mutagen. 2018. PMID: 29761828

4

A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage.

Li J, Beiser A, Dey NB, Takeda S, Saha LK, Hirota K, Parker LL, Carter M, Arrieta MI, Sobol RW. Li J, et al. Among authors: saha lk. NAR Genom Bioinform. 2022 Sep 13;4(3):lqac065. doi: 10.1093/nargab/lqac065. eCollection 2022 Sep. NAR Genom Bioinform. 2022. PMID: 36110898 Free PMC article.

5

Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC).

Sun Y, Saha S, Wang W, Saha LK, Huang SN, Pommier Y. Sun Y, et al. Among authors: saha lk, saha s. DNA Repair (Amst). 2020 May;89:102837. doi: 10.1016/j.dnarep.2020.102837. Epub 2020 Mar 7. DNA Repair (Amst). 2020. PMID: 32200233 Free PMC article. Review.

6

Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells.

Saha LK, Wakasugi M, Akter S, Prasad R, Wilson SH, Shimizu N, Sasanuma H, Huang SN, Agama K, Pommier Y, Matsunaga T, Hirota K, Iwai S, Nakazawa Y, Ogi T, Takeda S. Saha LK, et al. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14412-14420. doi: 10.1073/pnas.1920165117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513688 Free PMC article.

7

Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways.

Sun Y, Saha LK, Saha S, Jo U, Pommier Y. Sun Y, et al. Among authors: saha lk, saha s. DNA Repair (Amst). 2020 Oct;94:102926. doi: 10.1016/j.dnarep.2020.102926. Epub 2020 Jul 10. DNA Repair (Amst). 2020. PMID: 32674013 Free PMC article. Review.

8

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

Jo U, Murai Y, Chakka S, Chen L, Cheng K, Murai J, Saha LK, Miller Jenkins LM, Pommier Y. Jo U, et al. Among authors: saha lk. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2015654118. doi: 10.1073/pnas.2015654118. Proc Natl Acad Sci U S A. 2021. PMID: 33536335 Free PMC article.

9

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents.

Jo U, Senatorov IS, Zimmermann A, Saha LK, Murai Y, Kim SH, Rajapakse VN, Elloumi F, Takahashi N, Schultz CW, Thomas A, Zenke FT, Pommier Y. Jo U, et al. Among authors: saha lk. Mol Cancer Ther. 2021 Aug;20(8):1431-1441. doi: 10.1158/1535-7163.MCT-20-1026. Epub 2021 May 27. Mol Cancer Ther. 2021. PMID: 34045232 Free PMC article.

10

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.

Saha LK, Murai Y, Saha S, Jo U, Tsuda M, Takeda S, Pommier Y. Saha LK, et al. Among authors: saha s. Nucleic Acids Res. 2021 Oct 11;49(18):10493-10506. doi: 10.1093/nar/gkab777. Nucleic Acids Res. 2021. PMID: 34551432 Free PMC article.

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