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S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, Palumbo JS, Wainger BJ, Gallo RL, Leyva-Castillo JM, Vergnolle N, Price TJ, Ramachandran R, Horswill AR, Chiu IM. Deng L, et al. Among authors: leyva castillo jm. Cell. 2023 Nov 22;186(24):5375-5393.e25. doi: 10.1016/j.cell.2023.10.019. Cell. 2023. PMID: 37995657 Free PMC article.
Tick salivary glycans - a sugar-coated tick bite.
Karim S, Leyva-Castillo JM, Narasimhan S. Karim S, et al. Among authors: leyva castillo jm. Trends Parasitol. 2023 Dec;39(12):1100-1113. doi: 10.1016/j.pt.2023.09.012. Epub 2023 Oct 12. Trends Parasitol. 2023. PMID: 37838514 Review.
IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation.
Leyva-Castillo JM, Das M, Strakosha M, McGurk A, Artru E, Kam C, Alasharee M, Wesemann DR, Tomura M, Karasuyama H, Brombacher F, Geha RS. Leyva-Castillo JM, et al. J Allergy Clin Immunol. 2024 Dec;154(6):1462-1471.e3. doi: 10.1016/j.jaci.2024.06.021. Epub 2024 Jul 10. J Allergy Clin Immunol. 2024. PMID: 38996877
Basophils are important for development of allergic skin inflammation.
Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS. Leyva-Castillo JM, et al. J Allergy Clin Immunol. 2024 May;153(5):1344-1354.e5. doi: 10.1016/j.jaci.2024.01.022. Epub 2024 Feb 7. J Allergy Clin Immunol. 2024. PMID: 38336257
Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency.
Wilkie H, Das M, Pelovitz T, Bainter W, Woods B, Alasharee M, Sobh A, Baris S, Eltan SB, Al-Herz W, Barbouche MR, Ben-Mustapha I, Ben-Ali M, Sallam MTH, Awad A, Lotfy S, El Marsafy A, Ezzelarab M, Farrar M, Schmidt BAR, NandyMazumdar M, Guttman-Yassky E, Sheets A, Vidic KM, Murphy G, Schlievert PM, Chou J, Leyva-Castillo JM, Janssen E, Timilshina M, Geha RS. Wilkie H, et al. Among authors: leyva castillo jm. J Allergy Clin Immunol. 2024 Jul;154(1):143-156. doi: 10.1016/j.jaci.2023.12.020. Epub 2024 Jan 5. J Allergy Clin Immunol. 2024. PMID: 38185418
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with altered cornification and specific T cell expansion in atopic dermatitis.
Fiskin E, Eraslan G, Alora-Palli MB, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Deguine J, Smith GP, Geha R, Regev A, Xavier R. Fiskin E, et al. Among authors: leyva castillo jm. bioRxiv [Preprint]. 2023 Oct 31:2023.10.29.563503. doi: 10.1101/2023.10.29.563503. bioRxiv. 2023. PMID: 37961084 Free PMC article. Preprint.
IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin.
Leyva-Castillo JM, McGurk A, Strakosha M, Vega-Mendoza D, Smith SEM, Stafstrom K, Elkins M, Chou J, Wang YH, Geha RS. Leyva-Castillo JM, et al. J Allergy Clin Immunol. 2023 Oct;152(4):907-915. doi: 10.1016/j.jaci.2023.05.025. Epub 2023 Jun 12. J Allergy Clin Immunol. 2023. PMID: 37315811 Free PMC article.
35 results