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Page 1
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.
Krais JJ, Glass DJ, Chudoba I, Wang Y, Feng W, Simpson D, Patel P, Liu Z, Neumann-Domer R, Betsch RG, Bernhardy AJ, Bradbury AM, Conger J, Yueh WT, Nacson J, Pomerantz RT, Gupta GP, Testa JR, Johnson N. Krais JJ, et al. Among authors: pomerantz rt. Nat Commun. 2023 Nov 24;14(1):7714. doi: 10.1038/s41467-023-43446-1. Nat Commun. 2023. PMID: 38001070 Free PMC article.
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
Mateos-Gomez PA, Kent T, Deng SK, McDevitt S, Kashkina E, Hoang TM, Pomerantz RT, Sfeir A. Mateos-Gomez PA, et al. Among authors: pomerantz rt. Nat Struct Mol Biol. 2017 Dec;24(12):1116-1123. doi: 10.1038/nsmb.3494. Epub 2017 Oct 23. Nat Struct Mol Biol. 2017. PMID: 29058711 Free PMC article.
How RNA transcripts coordinate DNA recombination and repair.
McDevitt S, Rusanov T, Kent T, Chandramouly G, Pomerantz RT. McDevitt S, et al. Among authors: pomerantz rt. Nat Commun. 2018 Mar 15;9(1):1091. doi: 10.1038/s41467-018-03483-7. Nat Commun. 2018. PMID: 29545568 Free PMC article.
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Black SJ, et al. Among authors: pomerantz rt. Nat Commun. 2019 Sep 27;10(1):4423. doi: 10.1038/s41467-019-12272-9. Nat Commun. 2019. PMID: 31562312 Free PMC article.
Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Black SJ, et al. Among authors: pomerantz rt. Nat Commun. 2020 Apr 9;11(1):1831. doi: 10.1038/s41467-020-15551-y. Nat Commun. 2020. PMID: 32273507 Free PMC article.
Polλ promotes microhomology-mediated end-joining.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Chandramouly G, et al. Among authors: pomerantz rt. Nat Struct Mol Biol. 2023 Jan;30(1):107-114. doi: 10.1038/s41594-022-00895-4. Epub 2022 Dec 19. Nat Struct Mol Biol. 2023. PMID: 36536104 Free PMC article.
DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Vekariya U, Toma M, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, Jelinek J, Sliwinski T, Ghosh J, Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik M, Sykes SM, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta EM, Levine RL, Tallman MS, Fernandez HF, Litzow MR, Gupta GP, Masson JY, Skorski T. Vekariya U, et al. Among authors: pomerantz rt. Blood. 2023 May 11;141(19):2372-2389. doi: 10.1182/blood.2022018428. Blood. 2023. PMID: 36580665 Free PMC article.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Graña X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT. Calbert ML, et al. Among authors: pomerantz rt. Mol Cancer Ther. 2024 May 2;23(5):683-699. doi: 10.1158/1535-7163.MCT-23-0487. Mol Cancer Ther. 2024. PMID: 38064712
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, Auerbacher W, Calbert M, Rusanov T, Hoang T, Borisonnik N, Betsch R, Krais JJ, Wang Y, Vekariya UM, Gordon J, Morton G, Kent T, Skorski T, Johnson N, Childers W, Chen XS, Pomerantz RT. Fried W, et al. Among authors: pomerantz rt. Nat Commun. 2024 Apr 5;15(1):2862. doi: 10.1038/s41467-024-46593-1. Nat Commun. 2024. PMID: 38580648 Free PMC article.
42 results