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scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases.
Schäfer S, Smelik M, Sysoev O, Zhao Y, Eklund D, Lilja S, Gustafsson M, Heyn H, Julia A, Kovács IA, Loscalzo J, Marsal S, Zhang H, Li X, Gawel D, Wang H, Benson M. Schäfer S, et al. Among authors: heyn h. bioRxiv [Preprint]. 2023 Nov 13:2023.11.08.566249. doi: 10.1101/2023.11.08.566249. bioRxiv. 2023. Update in: Genome Med. 2024 Mar 20;16(1):42. doi: 10.1186/s13073-024-01314-7 PMID: 38014022 Free PMC article. Updated. Preprint.
scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases.
Schäfer S, Smelik M, Sysoev O, Zhao Y, Eklund D, Lilja S, Gustafsson M, Heyn H, Julia A, Kovács IA, Loscalzo J, Marsal S, Zhang H, Li X, Gawel D, Wang H, Benson M. Schäfer S, et al. Among authors: heyn h. Genome Med. 2024 Mar 20;16(1):42. doi: 10.1186/s13073-024-01314-7. Genome Med. 2024. PMID: 38509600 Free PMC article.
Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection.
Barmada A, Handfield LF, Godoy-Tena G, de la Calle-Fabregat C, Ciudad L, Arutyunyan A, Andrés-León E, Hoo R, Porter T, Oszlanczi A, Richardson L, Calero-Nieto FJ, Wilson NK, Marchese D, Sancho-Serra C, Carrillo J, Presas-Rodríguez S, Ramo-Tello C, Ruiz-Sanmartin A, Ferrer R, Ruiz-Rodriguez JC, Martínez-Gallo M, Munera-Campos M, Carrascosa JM, Göttgens B, Heyn H, Prigmore E, Casafont-Solé I, Solanich X, Sánchez-Cerrillo I, González-Álvaro I, Raimondo MG, Ramming A, Martin J, Martínez-Cáceres E, Ballestar E, Vento-Tormo R, Rodríguez-Ubreva J. Barmada A, et al. Among authors: heyn h. Eur J Immunol. 2024 Jan;54(1):e2350633. doi: 10.1002/eji.202350633. Epub 2023 Oct 20. Eur J Immunol. 2024. PMID: 37799110 Free article.
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.
García-Hernández V, Arambilet D, Guillén Y, Lobo-Jarne T, Maqueda M, Gekas C, González J, Iglesias A, Vega-García N, Sentís I, Trincado JL, Márquez-López I, Heyn H, Camós M, Espinosa L, Bigas A. García-Hernández V, et al. Among authors: heyn h. EMBO Mol Med. 2023 Feb 8;15(2):e16554. doi: 10.15252/emmm.202216554. Epub 2023 Jan 4. EMBO Mol Med. 2023. PMID: 36597789 Free PMC article.
Building a high-quality Human Cell Atlas.
Rozenblatt-Rosen O, Shin JW, Rood JE, Hupalowska A; Human Cell Atlas Standards and Technology Working Group; Regev A, Heyn H. Rozenblatt-Rosen O, et al. Among authors: heyn h. Nat Biotechnol. 2021 Feb;39(2):149-153. doi: 10.1038/s41587-020-00812-4. Nat Biotechnol. 2021. PMID: 33500565 No abstract available.
Integrative single-cell expression and functional studies unravels a sensitization to cytarabine-based chemotherapy through HIF pathway inhibition in AML leukemia stem cells.
Velasco-Hernandez T, Trincado JL, Vinyoles M, Closa A, Martínez-Moreno A, Gutiérrez-Agüera F, Molina O, Rodríguez-Cortez VC, Ximeno-Parpal P, Fernández-Fuentes N, Petazzi P, Beneyto-Calabuig S, Velten L, Romecin P, Casquero R, Abollo-Jiménez F, de la Guardia RD, Lorden P, Bataller A, Lapillonne H, Stam RW, Vives S, Torrebadell M, Fuster JL, Bueno C, Sarry JE, Eyras E, Heyn H, Menéndez P. Velasco-Hernandez T, et al. Among authors: heyn h. Hemasphere. 2024 Feb 26;8(2):e45. doi: 10.1002/hem3.45. eCollection 2024 Feb. Hemasphere. 2024. PMID: 38435427 Free PMC article.
Spatiotemporal omics for biology and medicine.
Liu L, Chen A, Li Y, Mulder J, Heyn H, Xu X. Liu L, et al. Among authors: heyn h. Cell. 2024 Aug 22;187(17):4488-4519. doi: 10.1016/j.cell.2024.07.040. Cell. 2024. PMID: 39178830 Review.
Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias.
Guerrero-Murillo M, Rill-Hinarejos A, Trincado JL, Bataller A, Ortiz-Maldonado V, Benítez-Ribas D, Español-Rego M, González-Navarro EA, Martínez-Cibrián N, Marchese D, Martín-Martín L, Martín García-Sancho A, Rives S, Heyn H, Juan M, Urbano-Ispizúa Á, Delgado J, Orfao A, Mereu E, Bueno C, Menendez P. Guerrero-Murillo M, et al. Among authors: heyn h. Cell Rep Med. 2024 Nov 19;5(11):101803. doi: 10.1016/j.xcrm.2024.101803. Epub 2024 Oct 28. Cell Rep Med. 2024. PMID: 39471818 Free PMC article.
139 results